1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Bifemelane hydrochloride

Bifemelane hydrochloride (Synonyms: MCI-2016)

Cat. No.: HY-B1558A
Handling Instructions

Bifemelane hydrochloride is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM, and it also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease.

For research use only. We do not sell to patients.

Bifemelane hydrochloride Chemical Structure

Bifemelane hydrochloride Chemical Structure

CAS No. : 62232-46-6

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Description

Bifemelane hydrochloride is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM, and it also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease[1][2].

IC50 & Target[1]

MAO-A

4.2 μM (Ki)

MAO-B

46 μM (Ki)

In Vitro

Bifemelane inhibits MAO-A in a dose-dependent manner, with Kis of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively[1].
Bifemelane inhibits MAO-B activities in a dose-dependent manner, with Kis of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively[1].

In Vivo

Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test[3].
Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg[3].

Animal Model: Wistar male rats (230-270 g) are induced hypothermia by Reserpine[3]
Dosage: 20, 40, 80 mg/kg
Administration: A single i.p.
Result: Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃.
Molecular Weight

305.84

Formula

C₁₈H₂₄ClNO

CAS No.

62232-46-6

SMILES

CNCCCCOC1=CC=CC=C1CC2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BifemelaneMCI-2016MCI2016MCI 2016Monoamine OxidaseMAOmonoamineoxidaseAMAO-AMAO-BantidepressantInhibitorinhibitorinhibit

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Bifemelane hydrochloride
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