1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Bifemelane hydrochloride

Bifemelane hydrochloride (Synonyms: MCI-2016)

Cat. No.: HY-B1558A Purity: 98.83%
Handling Instructions

Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease.

For research use only. We do not sell to patients.

Bifemelane hydrochloride Chemical Structure

Bifemelane hydrochloride Chemical Structure

CAS No. : 62232-46-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
5 mg USD 75 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
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25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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Description

Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease[1][2].

IC50 & Target[1]

MAO-A

4.2 μM (Ki)

MAO-B

46 μM (Ki)

In Vitro

Bifemelane inhibits MAO-A in a dose-dependent manner, with Kis of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively[1].
Bifemelane inhibits MAO-B activities in a dose-dependent manner, with Kis of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test[3].
Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar male rats (230-270 g) are induced hypothermia by Reserpine[3]
Dosage: 20, 40, 80 mg/kg
Administration: A single i.p.
Result: Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃.
Molecular Weight

305.84

Formula

C₁₈H₂₄ClNO

CAS No.
SMILES

CNCCCCOC1=CC=CC=C1CC2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (817.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2697 mL 16.3484 mL 32.6968 mL
5 mM 0.6539 mL 3.2697 mL 6.5394 mL
10 mM 0.3270 mL 1.6348 mL 3.2697 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.80 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BifemelaneMCI-2016MCI2016MCI 2016Monoamine OxidaseMAOmonoamineoxidaseAMAO-AMAO-BantidepressantInhibitorinhibitorinhibit

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Bifemelane hydrochloride
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HY-B1558A
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