62232-46-6
Chemical Structure
Bifemelane hydrochloride
Synonym(s): MCI-2016
- CAS No.: 62232-46-6
- Formula:C18H24ClNO
- Molecular Weight:305.84
IUPAC Name: 4-(2-benzylphenoxy)-N-methylbutan-1-amine hydrochloride
InChIKey: MEAHDXWXNNDSAK-UHFFFAOYSA-N
SMILES: CNCCCCOC1=CC=CC=C1CC2=CC=CC=C2.Cl
Biological Activity: Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease[1][2].
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Bifemelane hydrochloride | 99.86% | Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease. | ||||||||||||||||||||
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- [1]. Naoi M, et, al. 4-(O-benzylphenoxy)-N-methylbutylamine (bifemelane) and other 4-(O-benzylphenoxy)-N-methylalkylamines as new inhibitors of type A and B monoamine oxidase. J Neurochem. 1988 Jan; 50(1): 243-7. [Content Brief]
- [2]. Fasipe OJ, et, al. The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents. IBRO Rep. 2019 Jan 9; 6:95-110. [Content Brief]
Keywords
