MAO-B-IN-49
MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9 μM). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (HY-D1056) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750)-induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3098883-91-8
- 分子式: C19H20F2N2O3
- 分子量:362.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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hMAO-B 1 nM (IC50) |
hMAO-A 633.9 μM (IC50) |
MAO-B-IN-49 (Compound ZM24) (2-50 μM, 24 h) demonstrates cell viability exceeding 75 % across all tested conditions in HT22 cells[1].
MAO-B-IN-49 (5-20 μM, 24 h) is co-incubated with cells at different concentrations, and Lipopolysaccharides (HY-D1056) (LPS)-induced ROS production is significantly reduced in HT22 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT22 hippocampal neuronal cell line
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Concentration:2 μM, 5 μM, 10 μM, 20μM, 50 μM
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Incubation Time:24 h
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Result:Demonstrates cell viability exceeding 75 % across all tested conditions.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A Parkinson's disease model was induced in male C57BL/6J mice (2 months old, weighing 20±2 g) by injection of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)[1].
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Dosage:10 mg/kg, 30 mg/kg
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Administration:I.p., 30 mins before MPTP, once daily for 7 days
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Result:Led to a near-normal restoration of movement patterns, indicating a significant improvement in motor function.
Significantly improved the movement disorder in mice.
Effectively relieved forelimb muscle weakness in mice.
化学情報
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CAS 番号 3098883-91-8
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分子量 362.37
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分子式 C19H20F2N2O3
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SMILES
C[C@H](N1CCOC2=C(C1)C=CC(OCC3=CC(F)=C(C=C3)F)=C2)C(N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MAO-B-IN-49 関連分類
HY-178352 関連分類
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