3098883-91-8
Chemical Structure
MAO-B-IN-49
- CAS No.: 3098883-91-8
- Formula:C19H20F2N2O3
- Molecular Weight:362.37
InChIKey: JBPBSHDGLRWBKX-LBPRGKRZSA-N
SMILES: C[C@H](N1CCOC2=C(C1)C=CC(OCC3=CC(F)=C(C=C3)F)=C2)C(N)=O
Biological Activity: MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9 μM). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (HY-D1056) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750)-induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD[1].
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MAO-B-IN-49 | MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9 μM). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (HY-D1056) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750)-induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD. | |||||||||||||||||||||
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Keywords
