MAO-B-IN-47
MAO-B-IN-47 is a selective monoamine oxidase B (MAO-B) inhibitor with a Ki of 875 nM. MAO-B-IN-47 shows an IC50 >100 μM for SH-SY5Y cells. MAO-B-IN-47 shows neuroprotective effect in 6-OHDA-treated SH-SY5Y cells. MAO-B-IN-47 can be used for the research of neurological disease, such as Parkinson’s disease (PD).
For research use only. We do not sell to patients.
- CAS No.: 67082-01-3
- Formula: C16H13F3O
- Molecular Weight:278.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-B 875 nM (Ki) |
MAO-B-IN-47 (Compound 5a) (0-40 μM) shows no significant inhibitory effects on the proliferation of either normal (hSDFs, AT -MSCs) or cancer (A-375, U87-MG, SH-SY5Y) cells[1].
MAO-B-IN-47 (12.5-100 μM, 2 h) shows neuroprotective effect in 6-OHDA-treated SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:12.5 μM, 25 μM, 50 μM and 100μM
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Incubation Time:2 h followed by 6-OHDA for 24 h
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Result:Resulted in higher cell viability.
Significantly increased the IC50 of 6-OHDA at 12.5 μM and 25 μM.
Chemical Information
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CAS No. 67082-01-3
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Molecular Weight 278.27
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Formula C16H13F3O
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SMILES
O=C(C1=CC(C(F)(F)F)=CC=C1)CCC2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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