2. Metabolic Enzyme/Protease
  3. NAMPT
  4. SR-34831

SR-34831 is a NAMPT activator, NAD level stabilizer and neuroprotective agent. SR-34831 enhances the enzymatic activity of human NAMPT, prevents intracellular NAD depletion, and counteracts neuronal death induced by toxic misfolded prion proteins. SR-34831 exhibits metabolic stability in human liver microsomes and can be used for the research of protein misfolding neurodegenerative diseases.

For research use only. We do not sell to patients.

SR-34831

SR-34831 Chemical Structure

CAS No. : 2791469-19-5

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SR-34831 Related Antibodies

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Description

SR-34831 is a NAMPT activator, NAD level stabilizer and neuroprotective agent. SR-34831 enhances the enzymatic activity of human NAMPT, prevents intracellular NAD depletion, and counteracts neuronal death induced by toxic misfolded prion proteins. SR-34831 exhibits metabolic stability in human liver microsomes and can be used for the research of protein misfolding neurodegenerative diseases[1].

In Vitro

SR-34831 protects neuronal cells against TPrP-induced death with an EC50 of 20 nM[1].
SR-34831 shows metabolic stability in human hepatic microsomes, with a half-life of at least 15 minutes[1].
SR-34831 (1 μM) activates human NAMPT by at least 10% when tested at a concentration of 1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR-34831 Related Antibodies
Molecular Weight

452.60

Formula

C22H24N6OS2
CAS No.
SMILES

O=C(C(C=NN12)=C2NC(C3=CC=C(SCC)C=C3)=CC1=S)NCCCN4C=CN=C4C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SR-34831 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-348312791469-19-5SR34831SR 34831NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorneuronal cellsmisfolded prion proteinneuroprotective agentneuronal deathNADprotein misfolding neurodegenerative diseasesnicotinamide phosphoribosyltransferasehuman hepatic microsomesInhibitorinhibitorinhibit

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