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Cat. No.: HY-184246

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SR-34831

SR-34831 is a NAMPT activator, NAD level stabilizer and neuroprotective agent. SR-34831 enhances the enzymatic activity of human NAMPT, prevents intracellular NAD depletion, and counteracts neuronal death induced by toxic misfolded prion proteins. SR-34831 exhibits metabolic stability in human liver microsomes and can be used for the research of protein misfolding neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 2791469-19-5
Formula: C₂₂H₂₄N₆OS₂
Molecular Weight:452.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR-34831 Chemical Structure

CAS No.: 2791469-19-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

SR-34831 protects neuronal cells against TPrP-induced death with an EC₅₀ of 20 nM^[1].
SR-34831 shows metabolic stability in human hepatic microsomes, with a half-life of at least 15 minutes^[1].
SR-34831 (1 μM) activates human NAMPT by at least 10% when tested at a concentration of 1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2791469-19-5
Molecular Weight 452.60
Formula C₂₂H₂₄N₆OS₂
SMILES

O=C(C(C=NN12)=C2NC(C3=CC=C(SCC)C=C3)=CC1=S)NCCCN4C=CN=C4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gudmundsson K S, Johns B A. Substituted pyrazolo [1, 5-A] pyrimidinyls and pharmaceutical uses therefore: U.S. Patent 7,304,068[P]. 2007-12-4.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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