Protein deglycase DJ-1 against-1
Based on 1 publication(s) in Google Scholar
Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 724737-74-0
- Formula: C24H23N3O4
- Molecular Weight:417.46
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Protein deglycase DJ-1 against-1
MoreAll Dopamine Receptor Isoforms
More
Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks[1]
-
Dosage:1 mg/kg
-
Administration:IP; pretreatment one hour; daily; for 4 days
-
Result:Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.
Chemical Information
-
CAS No. 724737-74-0
-
Appearance Solid
-
Molecular Weight 417.46
-
Formula C24H23N3O4
-
Color White to off-white
-
SMILES
O=C(NC1=CC=C(C2=CN3C=CC=C(C)C3=N2)C=C1)C4=CC(OC)=C(OC)C(OC)=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Int Immunopharmacol
Identification and validation of PARK7 as a novel mitochondria-related signature associated with immune microenvironment in asthma. [Abstract]2025 Jun 5:157:114750. PMID: 40319751
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (239.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3954 mL | 11.9772 mL | 23.9544 mL | 59.8860 mL |
| 5 mM | 0.4791 mL | 2.3954 mL | 4.7909 mL | 11.9772 mL | |
| 10 mM | 0.2395 mL | 1.1977 mL | 2.3954 mL | 5.9886 mL | |
| 15 mM | 0.1597 mL | 0.7985 mL | 1.5970 mL | 3.9924 mL | |
| 20 mM | 0.1198 mL | 0.5989 mL | 1.1977 mL | 2.9943 mL | |
| 25 mM | 0.0958 mL | 0.4791 mL | 0.9582 mL | 2.3954 mL | |
| 30 mM | 0.0798 mL | 0.3992 mL | 0.7985 mL | 1.9962 mL | |
| 40 mM | 0.0599 mL | 0.2994 mL | 0.5989 mL | 1.4971 mL | |
| 50 mM | 0.0479 mL | 0.2395 mL | 0.4791 mL | 1.1977 mL | |
| 60 mM | 0.0399 mL | 0.1996 mL | 0.3992 mL | 0.9981 mL | |
| 80 mM | 0.0299 mL | 0.1497 mL | 0.2994 mL | 0.7486 mL | |
| 100 mM | 0.0240 mL | 0.1198 mL | 0.2395 mL | 0.5989 mL |
Protein deglycase DJ-1 against-1 Related Classifications
HY-137262 Related Classifications
Powered by Bioz