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Protein deglycase DJ-1 against-1 

Cat. No.: HY-137262
Handling Instructions

Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research.

For research use only. We do not sell to patients.

Protein deglycase DJ-1 against-1 Chemical Structure

Protein deglycase DJ-1 against-1 Chemical Structure

CAS No. : 724737-74-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research[1].

In Vivo

Protein deglycase DJ-1 against-1 (compound-23; 1 mg/kg; IP; pretreatment one hour; daily; for 4 days) significantly restores MPTP induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks[1]
Dosage: 1 mg/kg
Administration: IP; pretreatment one hour; daily; for 4 days
Result: Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.
Molecular Weight

417.46

Formula

C₂₄H₂₃N₃O₄

CAS No.
SMILES

O=C(NC1=CC=C(C2=CN3C=CC=C(C)C3=N2)C=C1)C4=CC(OC)=C(OC)C(OC)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (59.89 mM; ultrasonic and adjust pH to 7 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3954 mL 11.9772 mL 23.9544 mL
5 mM 0.4791 mL 2.3954 mL 4.7909 mL
10 mM 0.2395 mL 1.1977 mL 2.3954 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Protein deglycase DJ-1 against-1OthersInhibitorinhibitorinhibit

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Protein deglycase DJ-1 against-1
Cat. No.:
HY-137262
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