1. Others
  2. Others
  3. PB1

PB1 

Cat. No.: HY-138648 Purity: 98.99%
Handling Instructions

PB1 is a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogues. PB1 increases retinal ganglion cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB1 can be used for the research of neuroprotective.

For research use only. We do not sell to patients.

PB1 Chemical Structure

PB1 Chemical Structure

CAS No. : 188714-28-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 418 In-stock
Estimated Time of Arrival: December 31
Liquid
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PB1 is a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogues. PB1 increases retinal ganglion cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB1 can be used for the research of neuroprotective[1][2].

IC50 & Target

TCEP[1][2]

In Vitro

PB1-mediated RGC (retinal ganglion cells) neuroprotection does not involve the ASK1 pathway. PB1 produced a robust activation of the BDNF effector ERK1/2. PB1 promotes RGC survival[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PB1 (intraocular injection; 1 week) attenuates the loss of both RGC soma and axons in experimental glaucoma[1].
PB1 protects RGC (retinal ganglion cells) soma in experimental glaucoma. PB1 single dose limits the biological activity in vivo. PB1 attenuates the loss of both RGC soma and axons in experimental glaucoma[1]. PB1 (1~100000 nM; 72 hours) is effective at rescuing acutely axotomized retinal ganglion cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (180–200 g)
Dosage: Intraocular injection
Administration: 1 week
Result: PB1-treated eyes, 66% of RGCs survived at 1 week after axotomy.
Molecular Weight

296.11

Formula

C₁₄H₂₂BO₄P

CAS No.
SMILES

[H-][B+3]([P](CCC(OC)=O)(C1=CC=CC=C1)CCC(OC)=O)([H-])[H-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PB1PB 1PB-1OthersboraneretinalganglionxotomynanomolarpicomolarInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PB1
Cat. No.:
HY-138648
Quantity:
MCE Japan Authorized Agent: