1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Pseudoginsenoside F11

Pseudoginsenoside F11 (Synonyms: Ginsenoside A1)

Cat. No.: HY-N0541 Purity: >98.0%
Handling Instructions

Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice.

For research use only. We do not sell to patients.

Pseudoginsenoside F11 Chemical Structure

Pseudoginsenoside F11 Chemical Structure

CAS No. : 69884-00-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 93 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 106 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Biochemical experiments revealed that Pseudoginsenoside F11 (Ginsenoside A1) could inhibit diprenorphine (DIP) binding with an IC50 of 6.1 μM and reduced the binding potency of morphine in Chinese hamster ovary (CHO)-μ cells[1].

In Vivo

One in vivo model of cisplatin-induced acute renal failure was performed. The results showed that pretreatment with Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) reduced cisplatin-elevated blood urea nitrogen and creatinine levels, as well as ameliorated the histophathological damage [1]. We tested the effects of Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) on morphine-induced development of behavioral sensitization and alterations in glutamate levels in the medial prefrontal cortex (mPFC) in freely moving mice by using in vivo microdialysis. As the results shown, Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) antagonized the development of behavioral sensitization and decrease of glutamate in the mPFC induced by morphine[3].

Molecular Weight

801.01

Formula

C₄₂H₇₂O₁₄

CAS No.

69884-00-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (124.84 mM; Need ultrasonic)

H2O : 0.67 mg/mL (0.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2484 mL 6.2421 mL 12.4842 mL
5 mM 0.2497 mL 1.2484 mL 2.4968 mL
10 mM 0.1248 mL 0.6242 mL 1.2484 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (3.43 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (3.43 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (3.43 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Pseudoginsenoside F11Ginsenoside A1Pseudoginsenoside F 11Pseudoginsenoside F-11Ginsenoside A 1Ginsenoside A-1Endogenous MetaboliteInhibitorinhibitorinhibit

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Product name:
Pseudoginsenoside F11
Cat. No.:
HY-N0541
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