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  3. COG1410

COG1410 

Cat. No.: HY-P2136 Purity: 99.49%
Handling Instructions

COG1410 is an apolipoprotein E-derived peptide. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

COG1410 Chemical Structure

COG1410 Chemical Structure

CAS No. : 878009-24-6

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1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

COG1410 is an apolipoprotein E-derived peptide. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease[1][2].

In Vitro

COG1410 (1-25 μM; 48 h) decreases the production and release of NO and TNFα in BV2 microglia cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

COG1410 (0.3-0.6 mg/kg; a single i.v.) exhibits significant improvement on a short term test of vestibulomotor function and on a long term test of spatial learning and memory in mice[1].
COG1410 (0.8 mg/kg; a single i.v.) improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6J mice (12-16 weeks) with TBI[1]
Dosage: 0.3, 0.6 mg/kg
Administration: A single i.v. by tail vein
Result: Improved motor function on days 1-5 postinjury.
Significantly improved cognitive impairment.
Reduced the number of injured hippocampal neurons.
Suppressed the microglial activation.
Molecular Weight

1408.78

Formula

C₆₄H₁₂₁N₂₁O₁₄

CAS No.

878009-24-6

Sequence Shortening

Ac-AS-{Aib}-LRKL-{Aib}-KRLL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light, stored under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References
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Keywords:

COG1410COG 1410COG-1410ApoptosisapolipoproteinEpeptideneuroprotectiveantiinflammatorytraumaticbraininjuryTBIInhibitorinhibitorinhibit

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