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GPI-1046 

Cat. No.: HY-124619
Handling Instructions

GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models.

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GPI-1046 Chemical Structure

GPI-1046 Chemical Structure

CAS No. : 186452-09-5

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Description

GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2].

IC50 & Target[1]

GLT1

 

Molecular Weight

360.45

Formula

C₂₀H₂₈N₂O₄

CAS No.

186452-09-5

SMILES

O=C(OCCCC1=CC=CN=C1)[[email protected]]2N(C(C(C(C)(C)CC)=O)=O)CCC2

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Please store the product under the recommended conditions in the Certificate of Analysis.

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GPI-1046
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