186452-09-5
Chemical Structure
GPI-1046
- CAS No.: 186452-09-5
- Formula:C20H28N2O4
- Molecular Weight:360.45
IUPAC Name: 3-(pyridin-3-yl)propyl (3,3-dimethyl-2-oxopentanoyl)-L-prolinate
InChIKey: OQAHHWOPVDDWHD-INIZCTEOSA-N
SMILES: O=C(OCCCC1=CC=CN=C1)[C@H]2N(C(C(C(C)(C)CC)=O)=O)CCC2
Biological Activity: GPI-1046 is an orally active, antibiotic-free immunophilin ligand that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens core (NAc-core). GPI-1046 improves human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) by attenuating store-operated calcium (SOC) entry. GPI-1046 has neuroprotective activity[1][2][3].
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GPI-1046 | 99.79% | GPI-1046 is an orally active, antibiotic-free immunophilin ligand that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens core (NAc-core). GPI-1046 improves human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) by attenuating store-operated calcium (SOC) entry. GPI-1046 has neuroprotective activity. | ||||||||||||||||||||
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- [1]. Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35. [Content Brief]
- [2]. Höke A, et al. GPI-1046 protects dorsal root ganglia from gp120-induced axonal injury by modulating store-operated calcium entry. J Peripher Nerv Syst. 2009 Mar;14(1):27-35. [Content Brief]
- [3]. Ganel R, et al. Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiol Dis. 2006 Mar;21(3):556-67. [Content Brief]
Keywords
