c-ABL-IN-6
c-ABL-IN-6 (compound A6) is a c-ABL inhibitor with IC50 value of 16.6 nM. c-ABL-IN-6 displays higher neuroprotective effects against SH-SY5Y cell death induced by MPP+ (HY-W008719). c-ABL-IN-6 can be used for the research of neurodegenerative disorder.
For research use only. We do not sell to patients.
- Formula: C27H21F3N6O2
- Molecular Weight:518.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
c-Abl 16.6 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>80 μM
Compound: A6
|
Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 38006642] |
| L02 | IC50 |
>80 μM
Compound: A6
|
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 38006642] |
| SH-SY5Y | IC50 |
>80 μM
Compound: A6
|
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 38006642] |
Chemical Information
-
Molecular Weight 518.49
-
Formula C27H21F3N6O2
-
SMILES
CC1=CC=C(C(NC2=CC(C(F)(F)F)=CC(C3=CN(C)N=C3)=C2)=O)C=C1NC(C4=CN=C5C(C=CN5)=C4)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)