1. GPCR/G Protein
  2. Adenosine Receptor
  3. Adenosine amine congener

Adenosine amine congener (Synonyms: ADAC)

Cat. No.: HY-128064 Purity: 99.23%
Handling Instructions

Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects.

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Adenosine amine congener Chemical Structure

Adenosine amine congener Chemical Structure

CAS No. : 96760-69-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 317 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2].

IC50 & Target

A1 adenosine receptor[1][2]

In Vitro

Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways[1].

In Vivo

Adenosine amine congener (25-300 μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner[1].

Animal Model: Male Wistar rats (8-10 weeks old) treated with noise exposure[1]
Dosage: 25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300 μg/kg/day
Administration: Intraperitoneal injection; daily; for 5 days
Result: Most effective in the first 24 hours after noise exposure at doses >50 μg/kg, and provided up to 21 dB protection (averaged across 8-28 kHz).
Molecular Weight

576.60

Formula

C₂₈H₃₂N₈O₆

CAS No.

96760-69-9

SMILES

OC[[email protected]@H]1[[email protected]]([[email protected]]([[email protected]](N2C=NC3=C2N=CN=C3NC4=CC=C(CC(NC5=CC=C(CC(NCCN)=O)C=C5)=O)C=C4)O1)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (54.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7343 mL 8.6715 mL 17.3430 mL
5 mM 0.3469 mL 1.7343 mL 3.4686 mL
10 mM 0.1734 mL 0.8672 mL 1.7343 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.23%

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Keywords:

Adenosine amine congenerADACAdenosine ReceptorP1 receptorCochlearinjuryA1-adenosinehearinglosssystemicneuroprotectiveotoprotectiveapoptoticCa2+Inhibitorinhibitorinhibit

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Adenosine amine congener
Cat. No.:
HY-128064
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