1. Metabolic Enzyme/Protease
  2. Nampt

P7C3 

Cat. No.: HY-15976 Purity: 98.00%
Handling Instructions

P7C3 is a NAMPT activator.

For research use only. We do not sell to patients.

P7C3 Chemical Structure

P7C3 Chemical Structure

CAS No. : 301353-96-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 384 In-stock
Estimated Time of Arrival: December 31
100 mg USD 696 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of P7C3:

    P7C3 purchased from MCE. Usage Cited in: Int J Clin Exp Pathol 2018;11(1):293-303

    Expression of Nampt, RelB, Bax, PARP-1 is detected by western blot and hippocampal primary neuronal apoptosis by Flow cytometry. Nampt and RelB protein are up-regulated, and Bax, PARP-1 proteins are down-regulated by P7C3 stimulation in advance compared with Sev-N2O group.

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    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death. In vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity. In vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 33 mg/mL (69.59 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1089 mL 10.5443 mL 21.0886 mL
    5 mM 0.4218 mL 2.1089 mL 4.2177 mL
    10 mM 0.2109 mL 1.0544 mL 2.1089 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    474.19

    Formula

    C₂₁H₁₈Br₂N₂O

    CAS No.

    301353-96-8

    SMILES

    OC(CNC1=CC=CC=C1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    P7C3
    Cat. No.:
    HY-15976
    Quantity:

    P7C3

    Cat. No.: HY-15976