1. Metabolic Enzyme/Protease
  2. Nampt
  3. P7C3

P7C3 

Cat. No.: HY-15976 Purity: 99.97%
Handling Instructions

P7C3 is a NAMPT activator.

For research use only. We do not sell to patients.

P7C3 Chemical Structure

P7C3 Chemical Structure

CAS No. : 301353-96-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 384 In-stock
Estimated Time of Arrival: December 31
100 mg USD 696 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of P7C3:

Top Publications Citing Use of Products

Publications Citing Use of MCE P7C3

    P7C3 purchased from MCE. Usage Cited in: Int J Clin Exp Pathol 2018;11(1):293-303

    Expression of Nampt, RelB, Bax, PARP-1 is detected by western blot and hippocampal primary neuronal apoptosis by Flow cytometry. Nampt and RelB protein are up-regulated, and Bax, PARP-1 proteins are down-regulated by P7C3 stimulation in advance compared with Sev-N2O group.
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    • Customer Review

    Description

    P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death. In vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity. In vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.

    Molecular Weight

    474.19

    Formula

    C₂₁H₁₈Br₂N₂O

    CAS No.

    301353-96-8

    SMILES

    OC(CNC1=CC=CC=C1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 33 mg/mL (69.59 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1089 mL 10.5443 mL 21.0886 mL
    5 mM 0.4218 mL 2.1089 mL 4.2177 mL
    10 mM 0.2109 mL 1.0544 mL 2.1089 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.97%

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    Product Name:
    P7C3
    Cat. No.:
    HY-15976
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