1. Others
  2. Others
  3. P7C3-A20

P7C3-A20 

Cat. No.: HY-15978 Purity: 98.96%
Handling Instructions

P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment.

For research use only. We do not sell to patients.

P7C3-A20 Chemical Structure

P7C3-A20 Chemical Structure

CAS No. : 1235481-90-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 67 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 190 In-stock
Estimated Time of Arrival: December 31
100 mg USD 290 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of P7C3-A20:

Top Publications Citing Use of Products

Publications Citing Use of MCE P7C3-A20

    P7C3-A20 purchased from MCE. Usage Cited in: Neuroscience. 2020 Jun 3;S0306-4522(20)30353-5.

    P7C3-A20 alleviates HI injury. MAP-2 and MBP protein levels 7 days after HI in sham, HIE, and HIE + P7C3-A20 5 and 10 mg/kg groups.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment[1][2][3].

    In Vitro

    P7C3-A20 (10-100 μM; 8 hours; PC12 cells) treatment alleviates oxygen-glucose deprivation (OGD)-induced cytotoxicity in PC12 cells[1].
    P7C3-A20 (40-100 μM; 8 hours; PC12 cells) treatment alleviates OGD-induced apoptosis in PC12 cells[1].

    Cell Viability Assay[1]

    Cell Line: PC12 cells
    Concentration: 10 μM, 20 μM, 40 μM, 60 μM, 80 μM, 100 μM
    Incubation Time: 8 hours
    Result: Alleviated oxygen-glucose deprivation (OGD)-induced cytotoxicity in PC12 cells.

    Apoptosis Analysis[1]

    Cell Line: PC12 cells
    Concentration: 40 μM, 60 μM, 80 μM, 100 μM
    Incubation Time: 8 hours
    Result: Alleviated oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells.
    In Vivo

    P7C3-A20 (5-10 mg/kg; intraperitoneal injection; daily; for 7 days; Sprague-Dawley rats) treatment reduces infarct volume; reverses cell loss in the cortex and hippocampus and improves motor function without causing neurotoxicity in HI model rats. P7C3-A20 prevents HI-induced neuronal injury via activation of the PI3K/AKT/GSK3β signaling pathway[1].

    Animal Model: Sprague-Dawley rats (200-250 g) induced hypoxic-ischemic (HI) injury [1]
    Dosage: 5 mg/kg, 10 mg/kg
    Administration: Intraperitoneal injection; daily; for 7 days
    Result: Reduced infarct volume; reversed cell loss in the cortex and hippocampus and improved motor function without causing neurotoxicity.
    Molecular Weight

    506.21

    Formula

    C₂₂H₁₉Br₂FN₂O

    CAS No.

    1235481-90-9

    SMILES

    FC(CNC1=CC(OC)=CC=C1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (197.55 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9755 mL 9.8773 mL 19.7546 mL
    5 mM 0.3951 mL 1.9755 mL 3.9509 mL
    10 mM 0.1975 mL 0.9877 mL 1.9755 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3.85 mg/mL (7.61 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.96%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    P7C3-A20OthersHypoxic-ischemicneuroprotectiveinfarctPI3KAKTGSK3βBBBantidepressantInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    P7C3-A20
    Cat. No.:
    HY-15978
    Quantity:
    MCE Japan Authorized Agent: