LK-2
Based on 1 Customer Validation
LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable.
For research use only. We do not sell to patients.
- Purity: 98.83%
- CAS No.: 2649762-09-2
- Formula: C12H17N2O5P
- Molecular Weight:300.25
-
Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
| Species | Dose | Route | Cmax | Cmax (Brain) | T1/2 (Elimination) |
|---|---|---|---|---|---|
| Mice[1] | 30 mg/kg | i.p. | 92660 μg/L | 236 μg/L | 2.297 h |
Chemical Information
-
CAS No. 2649762-09-2
-
Appearance Solid
-
Molecular Weight 300.25
-
Formula C12H17N2O5P
-
Color White to off-white
-
SMILES
OP(C(C1=CC=CC=C1)N2CC(C(O)=O)NCC2)(O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 50 mg/mL (166.53 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3306 mL | 16.6528 mL | 33.3056 mL | 83.2639 mL |
| 5 mM | 0.6661 mL | 3.3306 mL | 6.6611 mL | 16.6528 mL | |
| 10 mM | 0.3331 mL | 1.6653 mL | 3.3306 mL | 8.3264 mL | |
| 15 mM | 0.2220 mL | 1.1102 mL | 2.2204 mL | 5.5509 mL | |
| 20 mM | 0.1665 mL | 0.8326 mL | 1.6653 mL | 4.1632 mL | |
| 25 mM | 0.1332 mL | 0.6661 mL | 1.3322 mL | 3.3306 mL | |
| 30 mM | 0.1110 mL | 0.5551 mL | 1.1102 mL | 2.7755 mL | |
| 40 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL | 2.0816 mL | |
| 50 mM | 0.0666 mL | 0.3331 mL | 0.6661 mL | 1.6653 mL | |
| 60 mM | 0.0555 mL | 0.2775 mL | 0.5551 mL | 1.3877 mL | |
| 80 mM | 0.0416 mL | 0.2082 mL | 0.4163 mL | 1.0408 mL | |
| 100 mM | 0.0333 mL | 0.1665 mL | 0.3331 mL | 0.8326 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz