1. GPCR/G Protein Neuronal Signaling
  2. Cannabinoid Receptor
  3. PM226

PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo.

For research use only. We do not sell to patients.

PM226 Chemical Structure

PM226 Chemical Structure

CAS No. : 1949726-13-9

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Description

PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo[1].

IC50 & Target[1]

CB2

13 nM (Ki)

CB2

39 nM (EC50)

In Vitro

PM226 binds selectively to CB2 receptor with an affinity in the nanomolar range (Ki=12.8±2.4 nM). PM226 has negligible affinity for the CB1 receptor (Ki >40000 nM) and no activity at the GPR55. PM226 was also evaluated in GTPγS binding assays specific to the CB2 receptor showing agonist activity (EC50=38.67±6.70 nM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PM226 (0.1, 1 and 10 mg/kg; administered i.p.) administration decreases the volume of the striatal lesion caused by Malonate[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Malonate-lesioned adult (12 week old; 350-400 g) male Wistar rats[2]
Dosage: 0.1, 1 and 10 mg/kg
Administration: Administered i.p.
Result: Reduced the volume of edema observed in Malonate-lesioned rats at the dose of 1 mg/kg.
Molecular Weight

357.49

Formula

C22H31NO3

CAS No.
SMILES

CC1(C)OC2=CC(C(C)(C)CCCCCC)=CC(OC)=C2C3=C1C=NO3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PM226
Cat. No.:
HY-136238
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