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TH-237A (Synonyms: meso-GS 164)

Cat. No.: HY-11054 Purity: 98.49%
Handling Instructions

TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier.

For research use only. We do not sell to patients.

TH-237A Chemical Structure

TH-237A Chemical Structure

CAS No. : 935467-97-3

Size Price Stock Quantity
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Solution
10 mM * 1 mL in DMSO USD 154 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 154 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Description

TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier. IC50 value: 5 nM (EC50, concentration that leads to a 50% increase in neuronal survival in the presence of the Aβ peptides) Target: Primary neurons were isolated from embryonic Sprague-Dawley rats, grown in culture (Michaelis et al., 1994) and exposed to either Aβ25-35 or Aβ1-42 in the presence or absence of TH-237A at concentrations ranging from 0.5 to 60 nM. The neurons were treated with TH-237A for 2 hours prior to exposure to the Aβ peptides. Changes in neuronal survival following treatment with TH 237A were evaluated using the Live/Dead assay. The EC50 for TH-237A was 5 nM, demonstrating that it had excellent neuroprotective properties.

Molecular Weight

333.33

Formula

C18H17F2NO3

CAS No.
SMILES

OCC12N([[email protected]](C3=CC=C(F)C=C3)OC2)[[email protected]@H](C4=CC=C(F)C=C4)OC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (300.00 mM; Need ultrasonic)

DMSO : ≥ 46 mg/mL (138.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0000 mL 15.0002 mL 30.0003 mL
5 mM 0.6000 mL 3.0000 mL 6.0001 mL
10 mM 0.3000 mL 1.5000 mL 3.0000 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
TH-237A
Cat. No.:
HY-11054
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