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  4. Moracenin D

Moracenin D is a natural flavonoid.

For research use only. We do not sell to patients.

Moracenin D

Moracenin D Chemical Structure

CAS No. : 78277-79-9

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Moracenin D Related Antibodies

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Description

Moracenin D is a natural flavonoid.

IC50 & Target[1]

Nurr1/NR4A2

 

α-synuclein

 

In Vitro

Moracenin D (0.16-4 μM; 24 h) protects SH-SY5Y cells against dopamine-induced cell death (EC50 = 3.6 μM)[1].
Moracenin D (0.16-4 μM; 9-15 h) up-regulates nurr1 expression and down-regulates α-synuclein expression in dopamine-treated cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Moracenin D Related Antibodies

Cell Viability Assay[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 0.16-4 μM
Incubation Time: 24 h
Result: Protected SH-SY5Y cells against dopamine-induced cell death with an EC₅₀ of 3.6 ± 0.9 μM

RT-PCR[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 0.16-4 μM
Incubation Time: 9 h
Result: Up-regulated nurr1 mRNA expression and down-regulated α-synuclein mRNA expression in a dose-dependent manner compared to the dopamine-alone group

Western Blot Analysis[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 0.16-4 μM
Incubation Time: 15 h
Result: Increased nurr1 protein expression and decreased α-synuclein protein expression in a dose-dependent manner compared to the dopamine-alone group
Molecular Weight

710.72

Formula

C40H38O12
CAS No.
SMILES

OC1=CC(O)=C(C(C(CCC(C)(O)C)=C(C2=C(C=C(C=C2)O)O)O3)=O)C3=C1[C@@H]4[C@H]([C@H](C5=C(C=C(C=C5)O)O)CC(C)=C4)C(C6=C(C=C(C=C6)O)O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Moracenin D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moracenin D78277-79-9Drug DerivativeDrug derivativehuman neuroblastoma cellsNurr1 mRNANurr1 agonistSH-SY5Y cellsα-synuclein regulatordopamine-exposed cellsα-synuclein mRNAParkinson’s diseaseneuroprotective agentdopamine-induced cell deathInhibitorinhibitorinhibit

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