1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. ABT-107

ABT-107 

Cat. No.: HY-108038
Handling Instructions

ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.

For research use only. We do not sell to patients.

ABT-107 Chemical Structure

ABT-107 Chemical Structure

CAS No. : 855291-54-2

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Description

ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions[1][2].

In Vivo

ABT-107 exhibits good bioavailability in mouse (orally, 51.1%; intraperitoneally,100%), rat (orally, 81.2%; intraperitoneally, 100.0%), and monkey (orally, 40.6%; intramuscularly, 100%), and good CNS penetration in rodents with a brain/plasma ratio of 1[1].
ABT-107 (0.01-1 μmol/kg i.p., 15 min before sacrifice) produces a dose-dependent increase in ERK1/2 and CREB[1].
ABT-107 (0.01, 0.1, and 1.0 mg/kg i.p.) increases S9-GSK3 and decreases p-tau in mouse cortex and hippocampus in mice[1].
ABT-107 (5 mg/kg/day i.p.) infusion attenuates tau hyperphosphorylation in AD transgenic APP-tau mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (male Sprague-Dawley; 350-380 g b.wt.)[1].
Dosage: 1, 3 μmol/kg.
Administration: I.P. daily for 3 consecutive days.
Result: Induced a significant, dose-dependent increase in ACh release by day 3 of repeated administration.
Higher doses may be required to evoke ACh release in naive rats not engaged in stimulated, i.e., cognitive-related behavior.
Animal Model: Female TAPP (and wild-type littermates) mice[1].
Dosage: 1 mg/kg.
Administration: Continuous subcutaneous infusion for 2 weeks.
Result: Produced a dose-dependent increase in Ser9 phosphorylation in the cingulate cortex 15 min after acute administration in mice.
Molecular Weight

320.39

Formula

C₁₉H₂₀N₄O

CAS No.
SMILES

[[email protected]]1(C2CCN(CC2)C1)OC3=CC=C(C4=CC=C(NC=C5)C5=C4)N=N3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ABT-107ABT107ABT 107nAChRNicotinic acetylcholine receptorsAlzheimer'sdiseaseneuroprotectiveInhibitorinhibitorinhibit

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ABT-107
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HY-108038
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