855291-54-2
855291-54-2
Chemical Structure
ABT-107
- CAS No.: 855291-54-2
- Formula:C19H20N4O
- Molecular Weight:320.39
IUPAC Name: (R)-3-((6-(1H-indol-5-yl)pyridazin-3-yl)oxy)quinuclidine
InChIKey: LUKNJAQKVPBDSC-SFHVURJKSA-N
SMILES: [C@H]1(C2CCN(CC2)C1)OC3=CC=C(C4=CC=C(NC=C5)C5=C4)N=N3
Biological Activity: ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ABT-107 | 99.73% | ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-19490VQW-765 -
Similarity Score 0.49
HY-100299ARPR107393 -
Similarity Score 0.49
HY-100299RPR107393 free base -
Similarity Score 0.47
HY-11035WAY-262611 -
Similarity Score 0.47
HY-W677714SDH-IN-43 -
Similarity Score 0.47
HY-19620Branaplam -
Similarity Score 0.47
HY-19620ABranaplam hydrochloride -
Similarity Score 0.47
HY-160440rel-VU6021625 -
Similarity Score 0.47
HY-160440AVU6021625 -
Explore the MedChemAI to find more analogs
References
- [1]. R Scott Bitner, et al. In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease. J Pharmacol Exp Ther. 2010 Sep 1;334(3):875-86. [Content Brief]
- [2]. Tanuja Bordia, et al. The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Exp Neurol. 2015 Jan;263:277-84. [Content Brief]
