VQW-765 (Synonyms: AQW-051)

Cat. No.: HY-19490 Purity: 99.34% ee.: 99.64%: FAQs
Data Sheet SDS COA Handling Instructions

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VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pK_D value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety.

For research use only. We do not sell to patients.

VQW-765 Chemical Structure

CAS No. : 669770-29-0

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 590	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of VQW-765:

(S)-VQW-765 In-stock

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Biological Activity
Purity & Documentation
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Description

In Vitro

VQW-765 shows a binding efficacy with a pK_D value of 7.56 to recombinantly expressed human α7-nACh receptor^[1].
VQW-765 shows a potent agonist activity to calcium transients that detected after stimulation of human α7-nACh receptors recombinantly expressed in GH3-ha7-22 cells with a pEC₅₀ value of 7.41^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VQW-765 (0.03 and 0.3 mg/kg; oral administration once) increases cognitive effect and learning/memory performance in mice^[1].
VQW-765 (1 mg/kg; oral administration once) shows anxiolytic-like effect with increasing the social exploration time in rats with a duration of at least 6 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	OF1/IC strain adult mice^[1]
Dosage:	0.03 and 0.3 mg/kg
Administration:	Oral administration; 0.03 and 0.3 mg/kg once
Result:	Increased the learning/memory performance with more time to scrutinize the novel partner than the familiar partner during the re-test trial at 24 h. Showed cognitive-enhancing effects in mice by the object recognition test (ORT).

Clinical Trial

Molecular Weight

294.39

Formula

C₁₉H₂₂N₂O

CAS No.

669770-29-0

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=C(C2=CC=C(O[C@H]3CN4CCC3CC4)C=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 16.67 mg/mL (56.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3969 mL	16.9843 mL	33.9685 mL
5 mM	0.6794 mL	3.3969 mL	6.7937 mL
10 mM	0.3397 mL	1.6984 mL	3.3969 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.34% ee.: 99.64%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) HNMR (369 KB) RP-HPLC (119 KB) NP-HPLC (208 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3969 mL	16.9843 mL	33.9685 mL	84.9214 mL
	5 mM	0.6794 mL	3.3969 mL	6.7937 mL	16.9843 mL
	10 mM	0.3397 mL	1.6984 mL	3.3969 mL	8.4921 mL
	15 mM	0.2265 mL	1.1323 mL	2.2646 mL	5.6614 mL
	20 mM	0.1698 mL	0.8492 mL	1.6984 mL	4.2461 mL
	25 mM	0.1359 mL	0.6794 mL	1.3587 mL	3.3969 mL
	30 mM	0.1132 mL	0.5661 mL	1.1323 mL	2.8307 mL
	40 mM	0.0849 mL	0.4246 mL	0.8492 mL	2.1230 mL
	50 mM	0.0679 mL	0.3397 mL	0.6794 mL	1.6984 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VQW-765669770-29-0AQW-051VQW765VQW 765AQW051AQW 051Inhibitorinhibitorinhibit

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