Midafotel  (Synonyms: SDZ-EAA 494)

Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED₅₀ value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects^[1][2][3].

Midafotel (15 mg/kg; i.p.) causes intense stereotyped behaviors in rats^[2].
Midafotel (1.5, 4.5, 15 mg/kg; i.v.; initiated 15 min prior to MCA occlusion (followed by constant infusion at 1, 3 or 10 mg/kg/h)) produces dose-dependent reductions in the volumes of infarction; the dose of 4.5 mg/kg being the most effective in focal cerebral ischemia in the rat^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

250.19

C₈H₁₅N₂O₅P

117414-74-1

OC([C@H]1CN(CCN1)C/C=C/P(O)(O)=O)=O

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• [1]. Lowe DA, et al. D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett. 1990 Jun 8;113(3):315-21.  [Content Brief]

  [2]. Potschka H, et al. Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats. Eur J Pharmacol. 1999 Jun 18;374(2):175-87.  [Content Brief]

  [3]. Park CK, McCulloch J, Kang JK, Choi CR. Efficacy of D-CPPene, a competitive N-methyl-D-aspartate antagonist in focal cerebral ischemia in the rat. Neurosci Lett. 1992 Nov 23;147(1):41-4.  [Content Brief]