117414-74-1
117414-74-1
Chemical Structure
Midafotel
Synonym(s): SDZ-EAA 494
- CAS No.: 117414-74-1
- Formula:C8H15N2O5P
- Molecular Weight:250.19
IUPAC Name: (R,E)-4-(3-phosphonoallyl)piperazine-2-carboxylic acid
InChIKey: VZXMZMJSGLFKQI-ABVWVHJUSA-N
SMILES: OC([C@H]1CN(CCN1)C/C=C/P(O)(O)=O)=O
Biological Activity: Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Midafotel | 99.00% | Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects. | ||||||||||||||||||||
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References
- [1]. Lowe DA, et al. D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett. 1990 Jun 8;113(3):315-21. [Content Brief]
- [2]. Potschka H, et al. Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats. Eur J Pharmacol. 1999 Jun 18;374(2):175-87. [Content Brief]
- [3]. Park CK, McCulloch J, Kang JK, Choi CR. Efficacy of D-CPPene, a competitive N-methyl-D-aspartate antagonist in focal cerebral ischemia in the rat. Neurosci Lett. 1992 Nov 23;147(1):41-4. [Content Brief]
