NS-417 free base 

NS-417 free base is an ERK1, ERK2, and Akt kinase activator with neuroprotective, neurite outgrowth potentiating, and dopaminergic cell population enhancing activity. NS-417 free base enhances activation of ERK1, ERK2, and Akt kinase via growth factor stimulation. NS-417 free base rescues cells from growth factor withdrawal-induced death, stimulates neurite outgrowth, increases tyrosine hydroxylase-positive cell counts, and displays neurotrophic-like activity in in vitro models. NS-417 free base can be used for the research of parkinson’s disease^[1].

NS-417 (0.01-10 μM; 4 days) free base prevents death of differentiated rat PC12 pheochromocytoma cells deprived of serum and NGF, with maximal survival effects observed at 2-5 μM after 4 days of incubation^[1].
NS-417 (1-3 μM; 2 days) free base induces short neurite-like processes in undifferentiated rat PC12 pheochromocytoma cells and significantly potentiates neurite outgrowth induced by NGF, bFGF, and EGF after 2 days of incubation^[1].
NS-417 (1-3 μM; 24 h) free base potentiates long-term (24-hour) NGF-induced ERK1/ERK2 and Akt activation in rat PC12 pheochromocytoma cells, and at 3 μM (10 min) enhances short-term (10-minute) ERK1/ERK2 activation induced by NGF, bFGF, and EGF^[1].
NS-417 (1 μM; 7 days) free base increases the number of tyrosine hydroxylase-positive dopaminergic neurons in dissociated E14 rat ventral mesencephalic cultures by 81% after 7 days of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

341.79

C₁₈H₁₆ClN₃O₂

160753-58-2

O=C1NC2=C(/C1=N/O)C=C(C3=C2CN(CC3)C)C4=CC=C(Cl)C=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dagø L, et al. NS-417, a novel compound with neurotrophic-like effects. Neurochem Res. 2002;27(1-2):107-111.  [Content Brief]