160753-58-2
Chemical Structure
NS-417 free base
- CAS No.: 160753-58-2
- Formula:C18H16ClN3O2
- Molecular Weight:341.79
InChIKey: JOKOUYPEQVYCOE-UHFFFAOYSA-N
SMILES: O=C1NC2=C(/C1=N/O)C=C(C3=C2CN(CC3)C)C4=CC=C(Cl)C=C4
Biological Activity: NS-417 free base is an ERK1, ERK2, and Akt kinase activator with neuroprotective, neurite outgrowth potentiating, and dopaminergic cell population enhancing activity. NS-417 free base enhances activation of ERK1, ERK2, and Akt kinase via growth factor stimulation. NS-417 free base rescues cells from growth factor withdrawal-induced death, stimulates neurite outgrowth, increases tyrosine hydroxylase-positive cell counts, and displays neurotrophic-like activity in in vitro models. NS-417 free base can be used for the research of parkinson’s disease[1].
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NS-417 free base | NS-417 free base is an ERK1, ERK2, and Akt kinase activator with neuroprotective, neurite outgrowth potentiating, and dopaminergic cell population enhancing activity. NS-417 free base enhances activation of ERK1, ERK2, and Akt kinase via growth factor stimulation. NS-417 free base rescues cells from growth factor withdrawal-induced death, stimulates neurite outgrowth, increases tyrosine hydroxylase-positive cell counts, and displays neurotrophic-like activity in in vitro models. NS-417 free base can be used for the research of parkinson’s disease. | |||||||||||||||||||||
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Keywords
