Carcinine dihydrochloride
Based on 1 Customer Validation
Carcinine (β-Alanylhistamine) dihydrochloride is the dihydrochloride salt of Carcinine (HY-107567). Carcinine is a selective and orally active histamine H3 receptor antagonist with a Ki of 0.2939 μM. Carcinine can reduce histamine content. Carcinine exhibits anti-oxidant activity and neuroprotective effects. Carcinine shows positive inotropic effect and can reduce blood sugar and blood lipid levels. Carcinine can be used for the researches of inflammation, neurological, cardiovascular and metabolic disease, such as retinal damage, seizure and diabetes.
For research use only. We do not sell to patients.
- Purity: 99.39%
- CAS No.: 57022-38-5
- Formula: C8H16Cl2N4O
- Molecular Weight:255.14
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Histamine Receptor Isoforms
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Biological Activity
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H3 receptor 0.2939 μM (Ki) |
H2 Receptor 365.3 μM (Ki) |
H1 Receptor 3621.2 μM (Ki) |
Carcinine (0.5 mM, 16 h) dihydrochloride forms a stable adduct with 4-HNE (HY-113466) a retention time of 17.5 mins[1].
Carcinine (1 μg-2 mg, 90 mins) dihydrochloride inhibits 4-HNE-induced modification of mouse retinal proteins with an IC50 of 33.2 μg/μL[1].
Carcinine (1 mg, 0-72 h) dihydrochloride reverses pre-formed 4-HNE-retinal protein adducts[1].
Carcinine (5 mM, 4-8 h) dihydrochloride rescues the protein level of retinol dehydrogenase 12 in mouse retinal explants treated with 4-HNE[1].
Carcinine dihydrochloride shows high affinity for histamine H3 receptor (Ki = 0.2939 μM) and extremely low affinity for H1 (Ki = 3621.2 μM) and H2 (Ki = 365.3 μM) receptors[2].
Carcinine (2-50 μM, 22.5 mins) dihydrochloride increases K+-induced endogenous 5-HT release but shows no effect on dopamine release in mouse forebrain slices[2].
Carcinine (10 mM) dihydrochloride scavenges hydroxyl radicals and inhibits deoxyribose damage[3].
Carcinine (10-25 mM, 60 mins) dihydrochloride reduces linoleic acid 13-monohydroperoxide (LOOH) and phosphatidylcholine hydroperoxide (PCOOH) in PC liposomes to hydroxy products (LOH)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Carcinine (0.2-20 mg/mouse, i.g., daily for 5 days) dihydrochloride protects the retina in BALB/c mice with bright light exposure[1].
Carcinine (5-50 mg/kg, i.p.) dihydrochloride decreases cortical and midbrain histamine content in ICR mice[2].
Carcinine (2-20 mg/kg, i.p., before PTZ) dihydrochloride significantly reduces the seizure stage induced by pentylenetetrazole (PTZ) in ICR mice[2].
Carcinine (10-20 mg/kg, i.p., 30 mins before scopolamine) dihydrochloride significantly ameliorates Scopolamine (HY-N0296)-induced learning deficit in ICR mice[2].
Carcinine (10-50 mg/kg, i.p.) dihydrochloride increases the total ambulation distance in ICR mice[2].
Carcinine (10-100 μg, heart injection via perfusate cannula) dihydrochloride shows positive inotropic effect in guinea pigs[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice with bright light exposure[1]
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Dosage:0.2, 2 and 20 mg/mouse
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Administration:Orally gavage, daily for 5 days
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Result:Showed that the rod a-wave amplitude increases from 84 μV to 257 μV, and the b-wave increaseed from 183 μV to 606 μV.
Decreased the loss rate of photoreceptor nuclei.
Prevented light-induced reduction of RDH12 protein level.
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Animal Model:Pentylenetetrazole (PTZ)-induced kindling mice models[2]
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Dosage:2, 10 and 20 mg/kg
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Administration:Intraperitoneally injection, before PTZ
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Result:Reduced the seizure stage.
Prolonged the latency to myoclonic jerks and latency to generalized clonic seizures.
Chemical Information
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CAS No. 57022-38-5
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Appearance Solid
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Molecular Weight 255.14
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Formula C8H16Cl2N4O
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Color White to off-white
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SMILES
O=C(NCCC1=CN=CN1)CCN.[H]Cl.[H]Cl
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Synonyms
β-Alanylhistamine dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 175 mg/mL (685.90 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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Handling Instructions (2659 KB)
References
[1]. Marchette LD, et al. Carcinine has 4-hydroxynonenal scavenging property and neuroprotective effect in mouse retina. Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3572-83. [Content Brief]
[2]. Chen Z, et al. Pharmacological effects of carcinine on histaminergic neurons in the brain. Br J Pharmacol. 2004 Nov;143(5):573-80. [Content Brief]
[3]. Babizhayev MA, et al. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. Biochem J. 1994 Dec 1;304 ( Pt 2)(Pt 2):509-16. [Content Brief]
[4]. Brotman DN, et al. Positive inotropic effect of carcinine in the isolated perfused guinea pig heart. Crit Care Med. 1990 Mar;18(3):317-21. [Content Brief]
[5]. Palmieri B, et al. The role of Carcinine treatment on glico-lipidic imbalance of patients with altered blood glucose pattern. Clin Ter. 2023 Mar-Apr;174(2):195-202. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.9194 mL | 19.5971 mL | 39.1942 mL | 97.9854 mL |
| 5 mM | 0.7839 mL | 3.9194 mL | 7.8388 mL | 19.5971 mL | |
| 10 mM | 0.3919 mL | 1.9597 mL | 3.9194 mL | 9.7985 mL | |
| 15 mM | 0.2613 mL | 1.3065 mL | 2.6129 mL | 6.5324 mL | |
| 20 mM | 0.1960 mL | 0.9799 mL | 1.9597 mL | 4.8993 mL | |
| 25 mM | 0.1568 mL | 0.7839 mL | 1.5678 mL | 3.9194 mL | |
| 30 mM | 0.1306 mL | 0.6532 mL | 1.3065 mL | 3.2662 mL | |
| 40 mM | 0.0980 mL | 0.4899 mL | 0.9799 mL | 2.4496 mL | |
| 50 mM | 0.0784 mL | 0.3919 mL | 0.7839 mL | 1.9597 mL | |
| 60 mM | 0.0653 mL | 0.3266 mL | 0.6532 mL | 1.6331 mL | |
| 80 mM | 0.0490 mL | 0.2450 mL | 0.4899 mL | 1.2248 mL | |
| 100 mM | 0.0392 mL | 0.1960 mL | 0.3919 mL | 0.9799 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Carcinine dihydrochloride Related Classifications
HY-107567B Related Classifications
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