2. Membrane Transporter/Ion Channel NF-κB
  3. Na+/K+ ATPase NF-κB
  4. 4-PSQ

4-PSQ is an orally active neuroprotective agent. 4-PSQ possesses both antioxidant and anti-inflammatory activities. 4-PSQ improves cognitive impairment and depressive- and anxiety-like emotional abnormalities in mice by regulating the activity of Na+, K+-ATPase, the NFκB signaling pathway, and the expression of p21. 4-PSQ can be used for the research of neurological diseases.

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4-PSQ

4-PSQ Chemical Structure

CAS No. : 1415931-33-7

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4-PSQ Related Antibodies

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Description

4-PSQ is an orally active neuroprotective agent. 4-PSQ possesses both antioxidant and anti-inflammatory activities. 4-PSQ improves cognitive impairment and depressive- and anxiety-like emotional abnormalities in mice by regulating the activity of Na+, K+-ATPase, the NFκB signaling pathway, and the expression of p21. 4-PSQ can be used for the research of neurological diseases[1].

In Vivo

4-PSQ (1 mg/kg; p.o.; daily; 10 days) reverses Vincristine (HY-N0488A)-induced impairments in cognitive, depression-like and anxiety-like behaviors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice with Vincristine (VCR)-induced neurotoxicity (male and female, 60 days old)[1]
Dosage: 1 mg/kg
Administration: p.o.; daily; days 7 to 16
Result: Restored short-term and long-term memory impairments induced by vincristine in both sexes.
Normalized depressive-like behavior in both sexes.
Reversed anxiety-like behavior in both sexes.
Counteracted vincristine-induced inhibition of Na+,K+-ATPase activity in the cerebral cortex, spinal cord, and cerebellum of male mice, and in the cerebellum of female mice.
Normalized vincristine-induced increased p21 mRNA expression in the cerebral cortex of female mice.
Normalized vincristine-induced increased NFκB mRNA expression in the cerebral cortex of male mice, and in the spinal cord of male and female mice.
Molecular Weight

318.66

Formula

C15H10ClNSe
CAS No.
SMILES

ClC1=CC=C2C([Se]C3=CC=CC=C3)=CC=NC2=C1
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Purity & Documentation
References
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4-PSQ Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-PSQ1415931-33-7Na+/K+ ATPaseNF-κBSodium potassium pumpNuclear factor-κBNuclear factor-kappaBanxiety-like behaviorSwiss miceglutamatergic pathwaysvincristinenitrergic pathwayscognitive impairmentdepressive-like behaviorInhibitorinhibitorinhibit

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