1. Apoptosis
    Immunology/Inflammation
    Autophagy
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. FKBP
    Calcium Channel
  3. ILS-920

ILS-920 

Cat. No.: HY-106345
Handling Instructions

ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12.

For research use only. We do not sell to patients.

ILS-920 Chemical Structure

ILS-920 Chemical Structure

CAS No. : 892494-07-4

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Description

ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12[1].

IC50 & Target

FKBP52[1]
L-type voltage-gated calcium channels (VGCC)[1]

In Vitro

ILS-920 promotes neuronal survival and stimulates neurite outgrowth with potent neurotrophic activities in cortical neuronal cultures[1].
ILS-920 can inhibit L-type Ca2+ channels in rat hippocampal neurons and F-11 dorsal root ganglia (DRG)/neuroblastoma cells. ILS-920 can protect neurons from Ca2+-induced cell death by modulating Ca2+ channels and promote neurite outgrowth via FKBP52 binding[1].

In Vivo

In a transient middle cerebral artery occlusion (tMCAO) model of ischemic stroke, ILS-920, administered 4 h postocclusion at 10 and 30 mg/kg, significantly reduces infarct volume by 24% and 23% in 72 h, respectively, and robustly enhances functional recovery measured by improvement in neurological deficits[1].

Molecular Weight

1023.30

Formula

C₅₇H₈₆N₂O₁₄

CAS No.

892494-07-4

SMILES
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Keywords:

ILS-920ILS920ILS 920FKBPCalcium ChannelFK506-binding proteinCa2+ channelsCa channelsCa2+homeostasisRapamycinneuroprotectiveFKBP52VGCCnonimmunosuppressiveimmunosuppressiveimmunophilinbrain-penetrantInhibitorinhibitorinhibit

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ILS-920
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HY-106345
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