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Cat. No.: HY-N7999

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Schisandrastemoside A

Schisandrastemoside A (Compound 3) is a lignan found in the rattan stems of Schisandra chinensis. Schisandrastemoside A shows neuroprotective efect and protects cells against Amyloid-beta 1-42 (HY-P1363A)-induced neurotoxicity. Schisandrastemoside A can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 2014382-50-2
Formula: C₂₈H₃₈O₁₂
Molecular Weight:566.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Schisandrastemoside A Chemical Structure

CAS No.: 2014382-50-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Schisandrastemoside A (5-25 μM; 24 h) potently protects PC12 cells from Amyloid-beta 1-42 (HY-P1363A)-induced toxicity in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC12 cells
Concentration:

5, 12.5, 25 μM
Incubation Time:

24 h ( with amyloid-beta 1-42 exposure)
Result:

Increased cell viability to 54.7 ± 3.4% at 5 μM.
Increased cell viability to 62.8 ± 3.8% at 12.5 μM.
Increased cell viability to 82.1 ± 4.3% at 25 μM.
Produced statistically significant increases in cell viability relative to the amyloid-beta 1-42-only model group at 12.5 μM and 25 μM.

Chemical Information

CAS No. 2014382-50-2
Molecular Weight 566.59
Formula C₂₈H₃₈O₁₂
SMILES

O[C@@]1(C)[C@H](C)CC2=CC(O)=C(OC)C(OC)=C2C3=C(C=C(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)C(OC)=C3OC)C1
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang BY, et al. New Thymoquinol Glycosides and Neuroprotective Dibenzocyclooctane Lignans from the Rattan Stems of Schisandra chinensis. Chem Biodivers. 2016 Sep;13(9):1118-1125. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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