YM-244769 hydrochloride (Standard)
YM-244769 hydrochloride (Standard) is the analytical standard of YM-244769 (hydrochloride) (HY-107659). This product is intended for research and analytical applications. YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.
For research use only. We do not sell to patients.
- CAS No.: 837424-39-2
- Formula: C26H23ClFN3O3
- Molecular Weight:479.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-107658
SN 6Na+/Ca2+ Exchanger Inhibitor -
HY-15754
CGP37157Na+/Ca2+ Exchanger Inhibitor -
HY-107659
YM-244769 hydrochlorideNCX Inhibitor -
HY-15415
KB-R7943 mesylateNCXrev Inhibitor -
HY-107658R
SN 6 (Standard)Reference Standard -
HY-B1546A
Benzamil hydrochlorideENaC Blocker -
HY-15515
SEA0400Na+/Ca2+ Exchanger Inhibitor -
HY-105064C
Zoniporide dihydrochlorideNHE1 Inhibitor -
HY-128678
ORM-10103Na+/Ca2+ Exchanger Inhibitor -
HY-123785
ORM-10962NCX Inhibitor -
HY-136182
YM-244769 dihydrochlorideNCX Inhibitor -
HY-15515R
SEA0400 (Standard)Na+/Ca2+ Exchanger Inhibitor
Biological Activity
Description
IC50 & Target
IC50: 18 nM (NCX3)[1]
Chemical Information
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CAS No. 837424-39-2
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Molecular Weight 479.93
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Formula C26H23ClFN3O3
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SMILES
O=C(C1=CN=C(C=C1)OC2=CC=C(C=C2)OCC3=CC(F)=CC=C3)NCC4=CC(N)=CC=C4.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
[1]. Iwamoto T, Kita S. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol Pharmacol. 2006 Dec;70(6):2075-83. [Content Brief]
[2]. Gotoh Y, et al. Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria. Biochem Biophys Res Commun. 2015 Jan 9;456(2):670-5. [Content Brief]
[3]. Yamashita K, et al. Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1205-1214. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YM-244769 hydrochloride (Standard) Related Classifications
HY-107659R Related Classifications
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