1. Cell Cycle/DNA Damage Epigenetics
  2. Sirtuin
  3. SRT3657

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.

For research use only. We do not sell to patients.

SRT3657 Chemical Structure

SRT3657 Chemical Structure

CAS No. : 1383551-17-4

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Description

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1].

IC50 & Target

SIRT1[1]

In Vivo

SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice[1].
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult double-transgenic CK-p25 mice (3-month-old)[1]
Dosage: 30 mg/kg
Administration: Oral gavage, daily, for 6 weeks
Result: Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.
Molecular Weight

774.97

Formula

C40H54N8O6S

CAS No.
SMILES

O=C(N1CCC(OCC2=CN=C(SC(C3=CC=CC=C3NC(C4=NC(CCCC)=NC(NCCN(C(OC(C)(C)C)=O)C)=C4)=O)=N5)C5=C2)CC1)OC(C)(C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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SRT3657 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SRT3657
Cat. No.:
HY-136094
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