1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin
  3. SRT3657

SRT3657 

Cat. No.: HY-136094
Handling Instructions

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.

For research use only. We do not sell to patients.

SRT3657 Chemical Structure

SRT3657 Chemical Structure

CAS No. : 1383551-17-4

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Description

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1].

IC50 & Target

SIRT1[1]

In Vivo

SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice[1].
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1].

Animal Model: Adult double-transgenic CK-p25 mice (3-month-old)[1]
Dosage: 30 mg/kg
Administration: Oral gavage, daily, for 6 weeks
Result: Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.
Molecular Weight

774.97

Formula

C₄₀H₅₄N₈O₆S

CAS No.

1383551-17-4

SMILES

O=C(N1CCC(OCC2=CN=C(SC(C3=CC=CC=C3NC(C4=NC(CCCC)=NC(NCCN(C(OC(C)(C)C)=O)C)=C4)=O)=N5)C5=C2)CC1)OC(C)(C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SRT3657SRT 3657SRT-3657SirtuinSIRT1neuroprotectivecaloricrestrictionsynapticneuronallossneurodegenerationmemoryimpairmentsInhibitorinhibitorinhibit

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SRT3657
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HY-136094
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