SRT3657
SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
For research use only. We do not sell to patients.
- CAS No.: 1383551-17-4
- Formula: C40H54N8O6S
- Molecular Weight:774.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SIRT1[1]
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult double-transgenic CK-p25 mice (3-month-old)[1]
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Dosage:30 mg/kg
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Administration:Oral gavage, daily, for 6 weeks
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Result:Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.
Chemical Information
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CAS No. 1383551-17-4
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Molecular Weight 774.97
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Formula C40H54N8O6S
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SMILES
O=C(N1CCC(OCC2=CN=C(SC(C3=CC=CC=C3NC(C4=NC(CCCC)=NC(NCCN(C(OC(C)(C)C)=O)C)=C4)=O)=N5)C5=C2)CC1)OC(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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