1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Fluoroethylnormemantine

Fluoroethylnormemantine 

Cat. No.: HY-139048
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Fluoroethylnormemantine, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects.

For research use only. We do not sell to patients.

Fluoroethylnormemantine Chemical Structure

Fluoroethylnormemantine Chemical Structure

CAS No. : 1639210-26-6

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Description

Fluoroethylnormemantine, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3].

IC50 & Target

NMDA receptor[1]

In Vivo

Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ 25-35-induced learning impairments in mice[1].
Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ 25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1].
Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1]
Dosage: 0.1, 0.3, 1, 3, 10 mg/kg
Administration: I.p. 30 minutes before the behavioral tests
Result: Attenuated Aβ 25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit.
Molecular Weight

197.29

Formula

C₁₂H₂₀FN

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FluoroethylnormemantineiGluRIonotropic glutamate receptorsMemantineNMDApositronemissiontomographyPETtracerantidepressantfearanti-amnesicneuroprotectiveAlzheimerInhibitorinhibitorinhibit

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Fluoroethylnormemantine
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