1639210-26-6
1639210-26-6
Chemical Structure
Fluoroethylnormemantine
- CAS No.: 1639210-26-6
- Formula:C12H20FN
- Molecular Weight:197.29
IUPAC Name: (1s,3r,5R,7S)-3-(2-fluoroethyl)adamantan-1-amine
InChIKey: HUYVZSFADWYSHD-CDECOKDKSA-N
SMILES: FCC[C@](C[C@H](C1)C2)(C[C@@H]1C3)C[C@]23N
Biological Activity: Fluoroethylnormemantine, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3].
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Fluoroethylnormemantine | 98.0% | Fluoroethylnormemantine, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects. | ||||||||||||||||||||
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References
- [1]. Couly S, et, al. Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease. Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157. [Content Brief]
- [2]. Chen BK, et, al. Fluoroethylnormemantine, a novel derivative of memantine, facilitates extinction learning without sensorimotor deficits. Int J Neuropsychopharmacol. 2021 Feb 25;pyab007. [Content Brief]
- [3]. Chen BK, et, al. Fluoroethylnormemantine, a novel NMDA receptor antagonist, for the prevention and treatment of stress-induced maladaptive behavior. Biological Psychiatry. 2021 May 9.
Keywords
