(R)-Chloro-butylphthalide-O-NBP
(R)-Chloro-butylphthalide-O-NBP, a chiral 3-n-butylphthalide derivative, is a neuroprotective agent. (R)-Chloro-butylphthalide-O-NBP shows potent blood-brain barrier (BBB) protective function. In vivo, (R)-Chloro-butylphthalide-O-NBP significantly reduces infarct volume and markedly preserves BBB integrity. (R)-Chloro-butylphthalide-O-NBP can be used for the research of ischemic stroke.
For research use only. We do not sell to patients.
- Formula: C18H17ClO4
- Molecular Weight:332.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(R)-Chloro-butylphthalide-O-NBP (compound R-30) (0.1 μM, 1 μM, 10 μM) demonstrates significant improvement in PC12 cell survival under OGD/R conditions[1].
(R)-Chloro-butylphthalide-O-NBP (0.1 μM, 1 μM, 10 μM) significantly reduces LDH release in OGD/R-injured PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In rats treated with (R)-Chloro-butylphthalide-O-NBP (i.v.; 100-200 mg/kg; once), body weight, food consumption, postmortem organ weight, and biochemical indicators remained normal, with no significant abnormalities observed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (SD) rats (middle cerebral artery occlusion (MCAO) model)[1]
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Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:i.v.; once
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Result:Significantly reduced infarct volume and preserved BBB integrity in a rat MCAO model.
At 10 and 20 mg/kg, significantly improved neurobehavioral scores and reduced cerebral infarction rates.
Also reduced Evans blue (EB) content in brain tissue, indicating protection against BBB damage.
Chemical Information
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Molecular Weight 332.78
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Formula C18H17ClO4
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SMILES
O=C1O[C@H](CCCOC2=CC=C(CO)C=C2)C3=C1C=C(Cl)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-Chloro-butylphthalide-O-NBP Related Classifications
HY-180267 Related Classifications
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