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  3. Drug Derivative
  4. (R)-Chloro-butylphthalide-O-NBP

(R)-Chloro-butylphthalide-O-NBP, a chiral 3-n-butylphthalide derivative, is a neuroprotective agent. (R)-Chloro-butylphthalide-O-NBP shows potent blood-brain barrier (BBB) protective function. In vivo, (R)-Chloro-butylphthalide-O-NBP significantly reduces infarct volume and markedly preserves BBB integrity. (R)-Chloro-butylphthalide-O-NBP can be used for the research of ischemic stroke.

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(R)-Chloro-butylphthalide-O-NBP

(R)-Chloro-butylphthalide-O-NBP Chemical Structure

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(R)-Chloro-butylphthalide-O-NBP Related Antibodies

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Description

(R)-Chloro-butylphthalide-O-NBP, a chiral 3-n-butylphthalide derivative, is a neuroprotective agent. (R)-Chloro-butylphthalide-O-NBP shows potent blood-brain barrier (BBB) protective function. In vivo, (R)-Chloro-butylphthalide-O-NBP significantly reduces infarct volume and markedly preserves BBB integrity. (R)-Chloro-butylphthalide-O-NBP can be used for the research of ischemic stroke[1].

In Vitro

(R)-Chloro-butylphthalide-O-NBP (compound R-30) (0.1 μM, 1 μM, 10 μM) demonstrates significant improvement in PC12 cell survival under OGD/R conditions[1].
(R)-Chloro-butylphthalide-O-NBP (0.1 μM, 1 μM, 10 μM) significantly reduces LDH release in OGD/R-injured PC12 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-Chloro-butylphthalide-O-NBP Related Antibodies
Parmacokinetics
Species Dose Route Cmax AUClast CL T1/2
Rat[1] 2 mg/kg i.v. 2915.90 ng/mL 461.96 ng·h/mL 74.34 mL/min/kg 3.13 h
Rat[1] 10 mg/kg i.v. 6552.32 ng/mL 2237.03 ng·h/mL 75.86 mL/min/kg 3.42 h
In Vivo

(R)-Chloro-butylphthalide-O-NBP (compound R-30) (5-20 mg/kg, i.v.) reduces infarct volume, improves neurobehavioral scores, and protects BBB integrity in a rat MCAO model of ischemic stroke[1].
In rats treated with (R)-Chloro-butylphthalide-O-NBP (i.v.; 100-200 mg/kg; once), body weight, food consumption, postmortem organ weight, and biochemical indicators remained normal, with no significant abnormalities observed[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) rats (middle cerebral artery occlusion (MCAO) model)[1]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: i.v.; once
Result: Significantly reduced infarct volume and preserved BBB integrity in a rat MCAO model.
At 10 and 20 mg/kg, significantly improved neurobehavioral scores and reduced cerebral infarction rates.
Also reduced Evans blue (EB) content in brain tissue, indicating protection against BBB damage.
Molecular Weight

332.78

Formula

C18H17ClO4
SMILES

O=C1O[C@H](CCCOC2=CC=C(CO)C=C2)C3=C1C=C(Cl)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R)-Chloro-butylphthalide-O-NBP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Chloro-butylphthalide-O-NBPDrug DerivativeDrug derivativeBBB protectiveMulti-functionalChiral resolutionIschemic strokeNeuroprotectionInhibitorinhibitorinhibit

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