1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Safinamide-d4-1

Safinamide-d4-1 (Synonyms: FCE 26743-d4-1; EMD 1195686-d4-1)

Cat. No.: HY-70057S1
Handling Instructions

Safinamide-d4-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.

For research use only. We do not sell to patients.

Safinamide-d4-1 Chemical Structure

Safinamide-d4-1 Chemical Structure

CAS No. : 2748522-33-8

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Description

Safinamide-d4-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

306.37

Formula

C17H15D4FN2O2

CAS No.
SMILES

FC1=CC=CC(COC2=C([2H])C([2H])=C(C([2H])=C2[2H])CN[[email protected]@H](C)C(N)=O)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Safinamide-d4-1
Cat. No.:
HY-70057S1
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