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  4. Retinestatin

Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP+ (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease.

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Retinestatin Chemical Structure

Retinestatin Chemical Structure

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Retinestatin Related Antibodies

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Description

Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP+ (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease[1].

In Vitro

Retinestatin (10 μM; pretreated for 24 h) significantly attenuates MPP+ (2 mM; 24 h)-induced cytotoxicity in SH-SY5Y dopaminergic neurons[1].
Retinestatin (10 μM; pretreated for 24 h) rescues the downregulated Bcl-xL and upregulated Bak expression induced by MPP+[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Retinestatin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: Pretreated for 24 h
Result: Significantly attenuated MPP+-induced cytotoxicity in SH-SY5Y dopaminergic neurons.

RT-PCR[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: Pretreated for 24 h
Result: Rescued the downregulated Bcl-xL and upregulated Bak expression induced by MPP+.
Molecular Weight

532.58

Formula

C25H40O12
SMILES

CCC/C=C/C=C/C=C/[C@@H](O)C[C@]1(O)O[C@H](C[C@H](O)[C@@H](O)[C@H](O)[C@@H](O2)[C@@H](O)[C@H](C)C2=O)[C@@H](O)[C@H](O)[C@@H]1O
Structure Classification
Initial Source

Streptomyces
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RetinestatinOtherspolyol polyketideSH-SY5YneuroprotectiveParkinson’s diseaseInhibitorinhibitorinhibit

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Retinestatin
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HY-N12657
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