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Cat. No.: HY-162385

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COX-2-IN-42

COX-2-IN-42 (Compound T1) is a COX-2 inhibitor, and protects zebrafish against PTZ-induced neuronal damage.

For research use only. We do not sell to patients.

Formula: C₃₀H₂₅N₅O₅S
Molecular Weight:567.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

COX-2-IN-42 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

COX-2-IN-42 (Compound T1) is a COX-2 inhibitor, and protects zebrafish against PTZ-induced neuronal damage^[1].

IC₅₀ & Target^[1]

COX-2

All COX Isoforms :

In Vivo

COX-2-IN-42 (50-150 μM, i.p.) protects Zebrafish against Pentylenetetrazole (PTZ) induced neuronal damage and epilepsy-like conditions in zebrafish model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pentylenetetrazole (10 mM) induced zebrafish model^[1]
Dosage:

50-150 μM
Administration:

i.p., 5 days a week for 4 week.
Result:

Increased survival, decreased ROS, prevented apoptosis and decreased macrophage localization.
Reduced the expression of COX-2 in brain tissue.

Chemical Information

Molecular Weight 567.62
Formula C₃₀H₂₅N₅O₅S
SMILES

O=S(C1=CC=C(N2N=C(C(N/N=C/C3=CC=CC(OC4=CC=CC=C4)=C3)=O)C=C2C5=CC=C(OC)C=C5)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Murugan R, et al. Neuroprotective potential of pyrazole benzenesulfonamide derivative T1 in targeted intervention against PTZ-induced epilepsy-like condition in in vivo zebrafish model. Int Immunopharmacol. 2024 Mar 15;131:111859. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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