2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-42

COX-2-IN-42 (Compound T1) is a COX-2 inhibitor, and protects zebrafish against PTZ-induced neuronal damage.

For research use only. We do not sell to patients.

COX-2-IN-42 Chemical Structure

COX-2-IN-42 Chemical Structure

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COX-2-IN-42 Related Antibodies

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Description

COX-2-IN-42 (Compound T1) is a COX-2 inhibitor, and protects zebrafish against PTZ-induced neuronal damage[1].

IC50 & Target[1]

COX-2

 

In Vivo

COX-2-IN-42 (50-150 μM, i.p.) protects Zebrafish against Pentylenetetrazole (PTZ) induced neuronal damage and epilepsy-like conditions in zebrafish model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pentylenetetrazole (10 mM) induced zebrafish model[1]
Dosage: 50-150 μM
Administration: i.p., 5 days a week for 4 week.
Result: Increased survival, decreased ROS, prevented apoptosis and decreased macrophage localization.
Reduced the expression of COX-2 in brain tissue.
Molecular Weight

567.62

Formula

C30H25N5O5S
SMILES

O=S(C1=CC=C(N2N=C(C(N/N=C/C3=CC=CC(OC4=CC=CC=C4)=C3)=O)C=C2C5=CC=C(OC)C=C5)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2-IN-42 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-42COXCyclooxygenaseneuroprotectiveInhibitorinhibitorinhibit

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