NBI-31772
Based on 3 publication(s) in Google Scholar
NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM). NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.88%
- CAS 番号: 374620-70-9
- 分子式: C17H11NO7
- 分子量:341.27
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 NBI-31772
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生物活性
NBI-31772 (0.1-10 µM; 24 h) stimulates the synthesis of IGF-1-dependent proteoglycans in human OA chondrocytes in a dose-dependent manner[3]. NBI-31772 (0.1-10 µM; 24 h) significantly stimulates the percentage of rabbit articular chondrocyte-associated proteoglycans in the presence of IGF-1 and IGFBP-3[3]. NBI-31772 (5-100 µM; 16 h) dose-dependently induces the maturation of zebrafish oocytes[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MCAO model rats[2]
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Dosage:5, 50 and 100 μg
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Administration:siv; Drug administration during ischemic episodes
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Result:Had similar effects on total lesion volume at the 50 and 100 μg doses.
Affected striatal lesion volume at the 50 μg dose.
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Animal Model:Intraluminal suture MCAO model rats[2]
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Dosage:50 μg
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Administration:i.v.; Administration 0, 1, 2, or 3 hours after MCAO
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Result:The greatest lesion reduction was observed when the drug was administered immediately after MCAO.
化学情報
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CAS 番号 374620-70-9
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性状 Solid
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分子量 341.27
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分子式 C17H11NO7
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Color Light yellow to brown
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SMILES
O=C(C1=CC(O)=C(O)C=C1)C2=NC(C(O)=O)=CC3=C2C=C(O)C(O)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
Apoptotic vesicles from macrophages exacerbate periodontal bone resorption in periodontitis via delivering miR-143-3p targeting Igfbp5. [Abstract]2024 Oct 26;22(1):658. PMID: 39456001 -
Int J Biol Macromol
Unveiling the mechanistic link between peroxiredoxin inhibition and ferroptosis-like cell death induced by Dinaciclib in Entamoeba histolytica. [Abstract]2026 Mar:350:150992. PMID: 41713546 -
溶剤 & 溶解度
DMSO : 125 mg/mL (366.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Khawaja XZ. Development of a scintillation proximity assay for human insulin-like growth factor-binding protein 4 compatible with inhibitor high-throughput screening. Anal Biochem. 2007;366(1):80-86. [Content Brief]
[2]. Mackay K B, et al. Neuroprotective effects of insulin-like growth factor-binding protein ligand inhibitors in vitro and in vivo[J]. Journal of Cerebral Blood Flow & Metabolism, 2003, 23(10): 1160-1167. [Content Brief]
[3]. De Ceuninck F, et al. Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes[J]. Arthritis Res Ther, 2004, 6: 1-11. [Content Brief]
[4]. Li J, et al. Insulin-like growth factor binding proteins inhibit oocyte maturation of zebrafish[J]. General and Comparative Endocrinology, 2019, 281: 83-90. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9302 mL | 14.6512 mL | 29.3023 mL | 73.2558 mL |
| 5 mM | 0.5860 mL | 2.9302 mL | 5.8605 mL | 14.6512 mL | |
| 10 mM | 0.2930 mL | 1.4651 mL | 2.9302 mL | 7.3256 mL | |
| 15 mM | 0.1953 mL | 0.9767 mL | 1.9535 mL | 4.8837 mL | |
| 20 mM | 0.1465 mL | 0.7326 mL | 1.4651 mL | 3.6628 mL | |
| 25 mM | 0.1172 mL | 0.5860 mL | 1.1721 mL | 2.9302 mL | |
| 30 mM | 0.0977 mL | 0.4884 mL | 0.9767 mL | 2.4419 mL | |
| 40 mM | 0.0733 mL | 0.3663 mL | 0.7326 mL | 1.8314 mL | |
| 50 mM | 0.0586 mL | 0.2930 mL | 0.5860 mL | 1.4651 mL | |
| 60 mM | 0.0488 mL | 0.2442 mL | 0.4884 mL | 1.2209 mL | |
| 80 mM | 0.0366 mL | 0.1831 mL | 0.3663 mL | 0.9157 mL | |
| 100 mM | 0.0293 mL | 0.1465 mL | 0.2930 mL | 0.7326 mL |
NBI-31772 関連分類
HY-110135 関連分類
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