2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. NBI-31772

NBI-31772 is the potent and nonselective inhibitor of IGFBP with a Ki value of 47 nM. NBI-31772 has the potential for the research of IGF-responsive diseases.

For research use only. We do not sell to patients.

NBI-31772 Chemical Structure

NBI-31772 Chemical Structure

CAS No. : 374620-70-9

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Based on 1 publication(s) in Google Scholar

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NBI-31772 Related Antibodies

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Description

NBI-31772 is the potent and nonselective inhibitor of IGFBP with a Ki value of 47 nM. NBI-31772 has the potential for the research of IGF-responsive diseases[1].

Molecular Weight

341.27

Formula

C17H11NO7
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(C1=CC(O)=C(O)C=C1)C2=NC(C(O)=O)=CC3=C2C=C(O)C(O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (366.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9302 mL 14.6512 mL 29.3023 mL
5 mM 0.5860 mL 2.9302 mL 5.8605 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.99%

COA (254 KB) HNMR (264 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9302 mL 14.6512 mL 29.3023 mL 73.2558 mL
5 mM 0.5860 mL 2.9302 mL 5.8605 mL 14.6512 mL
10 mM 0.2930 mL 1.4651 mL 2.9302 mL 7.3256 mL
15 mM 0.1953 mL 0.9767 mL 1.9535 mL 4.8837 mL
20 mM 0.1465 mL 0.7326 mL 1.4651 mL 3.6628 mL
25 mM 0.1172 mL 0.5860 mL 1.1721 mL 2.9302 mL
30 mM 0.0977 mL 0.4884 mL 0.9767 mL 2.4419 mL
40 mM 0.0733 mL 0.3663 mL 0.7326 mL 1.8314 mL
50 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4651 mL
60 mM 0.0488 mL 0.2442 mL 0.4884 mL 1.2209 mL
80 mM 0.0366 mL 0.1831 mL 0.3663 mL 0.9157 mL
100 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7326 mL
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NBI-31772 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NBI-31772374620-70-9NBI31772NBI 31772IGF-1RInsulin-like growth factor-1 receptorIGFBPIGF-responsive diseasesInhibitorinhibitorinhibit

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