1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Tiagabine hydrochloride

Tiagabine hydrochloride (Synonyms: NO050328 hydrochloride; NO328 hydrochloride; TGB hydrochloride)

Cat. No.: HY-B0696A Purity: 99.67%
Handling Instructions

Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively.

For research use only. We do not sell to patients.

Tiagabine hydrochloride Chemical Structure

Tiagabine hydrochloride Chemical Structure

CAS No. : 145821-59-6

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 158 In-stock
Estimated Time of Arrival: December 31
100 mg USD 264 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Tiagabine hydrochloride:

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Description

Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].

Clinical Trial
Molecular Weight

412.01

Formula

C20H26ClNO2S2

CAS No.
SMILES

O=C([[email protected]]1CN(CC/C=C(C2=C(C)C=CS2)/C3=C(C)C=CS3)CCC1)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (242.71 mM; Need ultrasonic)

DMSO : ≥ 53 mg/mL (128.64 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4271 mL 12.1356 mL 24.2713 mL
5 mM 0.4854 mL 2.4271 mL 4.8543 mL
10 mM 0.2427 mL 1.2136 mL 2.4271 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.05 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.05 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.67%

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Product Name:
Tiagabine hydrochloride
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HY-B0696A
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