2. Natural Products
  3. Plants
    Phenols
    Ketones, Aldehydes, Acids
  4. Asclepiadaceae
    Polyphenols
  5. Cynanchum paniculatum (Bunge) Kitagawa
  6. 2,3-Dihydroxy-4-methoxyacetophenone

2,3-Dihydroxy-4-methoxyacetophenone  (Synonyms: Gallacetophenone-4-methyl ether)

Cat. No.: HY-N7509 Purity: 99.63%
COA Handling Instructions

2,3-Dihydroxy-4-methoxyacetophenone is a neuroprotective compound from Cynenchum paniculatum. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may has the potential for the treatment of Alzheimer's disease research.

For research use only. We do not sell to patients.

2,3-Dihydroxy-4-methoxyacetophenone Chemical Structure

2,3-Dihydroxy-4-methoxyacetophenone Chemical Structure

CAS No. : 708-53-2

Size Price Stock Quantity
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 70 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

2,3-Dihydroxy-4-methoxyacetophenone is a neuroprotective compound from Cynenchum paniculatum. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may has the potential for the treatment of Alzheimer's disease research[1].

In Vitro

2,3-Dihydroxy-4-methoxyacetophenone protects HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50=10.94 μM). 2,3-Dihydroxy-4-methoxyacetophenone inhibits [Ca2+] accumulation in HT22 cells and has antioxidantive activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

2,3-dihydroxy-4-methoxyacetophenone (50mg/kg; po) improves the impairment of spatial memory induced by scopolamine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

182.17

Appearance

Solid

Formula

C9H10O4
CAS No.
SMILES

CC(C1=CC=C(OC)C(O)=C1O)=O
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (548.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4894 mL 27.4469 mL 54.8938 mL
5 mM 1.0979 mL 5.4894 mL 10.9788 mL
10 mM 0.5489 mL 2.7447 mL 5.4894 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

2,3-Dihydroxy-4-methoxyacetophenone708-53-2Gallacetophenone-4-methyl etherOthersInhibitorinhibitorinhibit

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