1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3
  3. BIP-135

BIP-135 

Cat. No.: HY-111055 Purity: 98.31%
Handling Instructions

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.

For research use only. We do not sell to patients.

BIP-135 Chemical Structure

BIP-135 Chemical Structure

CAS No. : 941575-71-9

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1 mg USD 125 In-stock
Estimated Time of Arrival: December 31
5 mg USD 365 In-stock
Estimated Time of Arrival: December 31
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Description

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].

IC50 & Target

GSK-3α

16 nM (IC50)

GSK-3β

21 nM (IC50)

In Vitro

BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1].
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress[1].

Western Blot Analysis[1]

Cell Line: Human SMA fibroblasts
Concentration: 20 μM, 25 μM, 30 μM
Incubation Time: 72 hours
Result: Led to a 7-fold increase in SMN levels at 25 μM.
In Vivo

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy[1].

Animal Model: Male and female SMN2+/+, SMN2Δ7+/+, Smn+/– mice[1]
Dosage: 75 mg/kg
Administration: Intraperitoneal injection; daily; from postnatal day 0 to 21
Result: Caused a modest extension in the median survival of SMA KO animals by two days.
Molecular Weight

421.24

Formula

C₂₁H₁₃BrN₂O₃

CAS No.

941575-71-9

SMILES

O=C(C(C1=COC2=CC=CC=C12)=C3C4=CN(C)C5=C4C=C(Br)C=C5)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

BIP-135BIP135BIP 135GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3neuroprotectiveSMNspinalmuscularatrophy,SMAInhibitorinhibitorinhibit

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BIP-135
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