Dimephosphon
Dimephosphon is an anti-inflammatory agent with antihistamine and antiserotonin activities. Dimephosphon helps maintain the conduction function of the spinal cord and reduces the excitability of spinal motor neurons in the area surrounding the lesion. Dimephosphon directly activates lymphatic vessel movement and improves lymphatic circulation. Dimephosphon can be used for the study of inflammatory edema, acute spinal cord injury and lymphatic circulation disorders.
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- CAS No.: 14394-26-4
- Formule: C8H17O4P
- Masse moléculaire:208.19
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Dimephosphon (2.5 % Dimephosphon Solution, 1 mL, daily for 10 days) promotes the recovery of spinal cord conduction function, and its mechanism may be related to anti-edema, vascular protection and reduction of neuronal hyperexcitability, in hybrid dogs with spinal cord injury[2].
Dimephosphon (50 mg/kg, i.p, once dose) enhances lymphatic circulation by directly activating lymphatic vessel contraction (stimulating vessel wall and valve muscle cells) in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino rats (200-230 g)[3]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection (i.p.), once dose
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Result:Increased the thoracic duct (TLD) lymph flow rate to 1.4 times that of the control group, and enhanced the contraction activity of lymphatic vessels. Increased the number of functional lymphatic vessels and the number of mesenteric lymphatic vessels by 1.5 times
Chemical Information
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CAS No. 14394-26-4
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Masse moléculaire 208.19
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Formule C8H17O4P
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SMILES
O=C(CC(C)(P(OC)(OC)=O)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ziganshina LE, et al. [Effect of dimephosphon on the inflammatory reaction]. Farmakol Toksikol. 1988 May-Jun;51(3):58-60. [Content Brief]
[2]. A M Eremeev, et al. Effect of Dimephosphon on Functional Recovery of Damaged Spinal Cord. Bull Exp Biol Med. 2006 Feb;141(2):181-3. [Content Brief]
[3]. R Kh Khafiz'yanova, et al. Lymphotropic Effect of Dimephosphon, Mexidol, and Ketorolac is Realized via Activation of the Lymphangion and Stimulation of Lymph Formation. Bull Exp Biol Med. doi: 10.1007/s10517-007-0152-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dimephosphon Related Classifications
HY-176248 Related Classifications
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