FAAH-IN-7 

FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC₅₀ value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model^[1].

FAAH-IN-7 (compound 4e) (10 nM-30 μM; 24 h) has no cytotoxicity against mouse fibroblasts NIH3T3 and human astrocytes cell line 1321N1 with K_i values >10 μM^[1].
FAAH-IN-7 (10 nM, 100 nM; 30 min) inhibits FAAH through a reversible mechanism in the case of rapid dilution. The rapid dilution disrupts the equilibrium between the inhibitor and the enzyme, resulting in enzymatic activity recovery^[1].
FAAH-IN-7 (1 nM-1 μM; 24 h) significantly reduces ROS production starting from the 10 nM concentration in 1321N1 astrocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FAAH-IN-7 (compound 4e) shows anti-inflammatory effects in inflammation-induced neurodegenerated ex vivo cultures of rat hippocampal explants^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

447.53

C₂₆H₂₉N₃O₄

3037600-36-2

O=C(N1CCN(CCCC2=CC=CC=C2)CC1)OC3=CC=CC(C4=C(C(N)=O)C=C(C)O4)=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Papa A, et al. Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. Eur J Med Chem. 2022 Nov 25;246:114952.  [Content Brief]