1. Metabolic Enzyme/Protease Neuronal Signaling
  2. FAAH
  3. FAAH-IN-7

FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC50 value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model.

For research use only. We do not sell to patients.

FAAH-IN-7 Chemical Structure

FAAH-IN-7 Chemical Structure

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Description

FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC50 value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model[1].

In Vitro

FAAH-IN-7 (compound 4e) (10 nM-30 μM; 24 h) has no cytotoxicity against mouse fibroblasts NIH3T3 and human astrocytes cell line 1321N1 with Ki values >10 μM[1].
FAAH-IN-7 (10 nM, 100 nM; 30 min) inhibits FAAH through a reversible mechanism in the case of rapid dilution. The rapid dilution disrupts the equilibrium between the inhibitor and the enzyme, resulting in enzymatic activity recovery[1].
FAAH-IN-7 (1 nM-1 μM; 24 h) significantly reduces ROS production starting from the 10 nM concentration in 1321N1 astrocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: 1321N1 human astrocytes
Concentration: 10 nM, 100 nM, 1 μM, 10 μM, and 30 μM
Incubation Time: 24 hours
Result: Showed no cytotoxicity against 1321N1 human astrocytes.
In Vivo

FAAH-IN-7 (compound 4e) shows anti-inflammatory effects in inflammation-induced neurodegenerated ex vivo cultures of rat hippocampal explants[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

447.53

Formula

C26H29N3O4

SMILES

CC1=CC(C(N)=O)=C(O1)C2=CC=CC(OC(N3CCN(CC3)CCCC4=CC=CC=C4)=O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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FAAH-IN-7 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
FAAH-IN-7
Cat. No.:
HY-151919
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