2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. VK-28

VK-28 is a blood-brain barrier-permeable iron chelator. VK-28 inhibits mitochondrial membrane lipid peroxidation and the iron-dependent generation of reactive hydroxyl radicals. VK-28 exhibits neuroprotective activity and protects rats against 6-OHDA-induced striatal dopaminergic damage. VK-28 can be used in studies related to Parkinson's disease.

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VK-28

VK-28 Chemical Structure

CAS No. : 312611-92-0

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Based on 1 publication(s) in Google Scholar

VK-28 Related Antibodies

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Description

VK-28 is a blood-brain barrier-permeable iron chelator. VK-28 inhibits mitochondrial membrane lipid peroxidation and the iron-dependent generation of reactive hydroxyl radicals. VK-28 exhibits neuroprotective activity and protects rats against 6-OHDA-induced striatal dopaminergic damage. VK-28 can be used in studies related to Parkinson's disease[1][2].

In Vitro

VK-28 (10-7-10-3 M; 90 min) potently inhibits basal lipid peroxidation and iron-induced lipid peroxidation in mitochondrial membrane homogenates from rat cerebral cortex, with an IC50 of 12.7 µM[1].
VK-28 (1-10 μM; 24 h) exhibits neuroprotective activity by reducing serum deprivation-induced PC12 cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VK-28 Related Antibodies

ELISA Assay[2]

Cell Line: PC12 cells
Concentration: 1 μM, 10 μM
Incubation Time: 24 h
Result: Rescued PC12 cells from serum-free induced death, resulting in ~1000% of control OD at 1 μM and ~900% of control OD at 10 μM.
Reduced cell death compared to untreated serum-free cells.
Showed neuroprotective activity comparable to rasagiline.
In Vivo

VK-28 (1 µg; intracerebroventricular injection; single administration) fully protects male Sprague-Dawley rats against striatal dopaminergic damage induced by intracerebroventricular injection of 6-OHDA (HY-B1081A), maintains DA, DOPAC and HVA levels, and normalizes dopamine turnover[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 230-270 g, 8-10 per group, intracerebroventricular 6-hydroxydopamine-induced striatal dopaminergic lesion)[1]
Dosage: 1 µg
Administration: i.c.v.; single dose (30 minutes before 6-OHDA)
Result: Prevented the 78% reduction in striatal dopamine (DA), 73% reduction in dihydroxyphenylacetic acid (DOPAC), and 59% reduction in homovanilic acid (HVA) caused by 6-OHDA alone.
Reduced the 6-OHDA-induced increase in striatal dopamine turnover ratio (DOPAC+HVA/DA) to near baseline levels.
Left striatal serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), and norepinephrine (NE) concentrations unaffected.
Molecular Weight

287.36

Formula

C16H21N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCCN1CCN(CC1)CC2=C3C=CC=NC3=C(C=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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VK-28 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VK-28312611-92-0VK28VK 28Dopamine ReceptorParkinson’s disease6-hydroxydopaminePC12 cellsmale Sprague-Dawley ratsrat brain cortical mitochondrial membrane homogenatesmitochondrial membrane lipid peroxidationblood-brain barrierMPTPFenton chemistryreactive hydroxyl radicalsInhibitorinhibitorinhibit

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