312611-92-0
312611-92-0
Chemical Structure
VK-28
- CAS No.: 312611-92-0
- Formula:C16H21N3O2
- Molecular Weight:287.36
IUPAC Name: 5-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)quinolin-8-ol
InChIKey: XIXFNVDWEWCEOI-UHFFFAOYSA-N
SMILES: OCCN1CCN(CC1)CC2=C3C=CC=NC3=C(C=C2)O
Biological Activity: VK-28 is a blood-brain barrier-permeable iron chelator. VK-28 inhibits mitochondrial membrane lipid peroxidation and the iron-dependent generation of reactive hydroxyl radicals. VK-28 exhibits neuroprotective activity and protects rats against 6-OHDA-induced striatal dopaminergic damage. VK-28 can be used in studies related to Parkinson's disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VK-28 | 97.17% | VK-28 is a blood-brain barrier-permeable iron chelator. VK-28 inhibits mitochondrial membrane lipid peroxidation and the iron-dependent generation of reactive hydroxyl radicals. VK-28 exhibits neuroprotective activity and protects rats against 6-OHDA-induced striatal dopaminergic damage. VK-28 can be used in studies related to Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. Shachar DB, et al. Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. Neuropharmacology. 2004;46(2):254-263. [Content Brief]
- [2]. Youdim MB, et al. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases. Mech Ageing Dev. 2005;126(2):317-326. [Content Brief]
