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Cat. No.: HY-178362

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CAII/VII-IN-1

CAII/VII-IN-1 is an orally active hCA II (K_I = 12.3 nM), and hCA VII (K_I = 22.6 nM) inhibitor, showing no significant activity against hCA I. CAII/VII-IN-1 shows excellent neuroprotective activity in vivo Pilocarpine (HY-B0726A)-induced seizure model. CAII/VII-IN-1 can upregulate KCC2 and inhibit mTOR, exerting neuroprotective effects. CAII/VII-IN-1 does not show any significant neurotoxic effects or alterations in liver and kidney function. CAII/VII-IN-1 can be used for the study of epilepsy.

For research use only. We do not sell to patients.

CAS No.: 3085155-69-4
Formula: C₂₇H₂₃ClN₈O₅S₂
Molecular Weight:639.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CAII/VII-IN-1 Chemical Structure

CAS No.: 3085155-69-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Carbonic Anhydrase Isoforms :

All mTOR Isoforms :

In Vitro

CAII/VII-IN-1 (Compound 16d) is safe at the given concentration in Vero cells (IC₅₀ = 59.7 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CAII/VII-IN-1 (200 mg/kg, oral gavage, once) produces pronounced anti-convulsant and anti-epileptogenic effects in Pilocarpine-induced mice, as manifested by a two-fold increase in seizure onset latency, a substantial reduction in seizure severity, and the restoration of hippocampal homeostasis ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male mice (20-25 g) were injected with Pilocarpine^[1].
Dosage:

200 mg/kg
Administration:

Orally before Pilocarpine injection
Result:

Delayed seizures by more than twice as long as the Pilocarpine group (108.6 %).
Showed comparable efficacy in delaying seizure onset and reducing severity at most time points.
Reached 100 % survival.
Upregulated KCC2 (188.1%) and inhibited mTOR (51.39%) exert neuroprotective effects.

Chemical Information

CAS No. 3085155-69-4
Molecular Weight 639.11
Formula C₂₇H₂₃ClN₈O₅S₂
SMILES

ClC1=CC=C(C=C1)C2=NN(C=C2/C=N/NC(C3=C(N(N=N3)C4=CC=C(C=C4)S(N)(=O)=O)C)=O)C5=CC=C(C=C5)S(C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. ie Y, et al. Development of potent glutathione transferase Omega-1 inhibitors with applications in inflammation and cancer therapy. Eur J Med Chem. 2025 Dec 5;299:118072. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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CAII/VII-IN-1

All Carbonic Anhydrase Isoforms

All mTOR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CAII/VII-IN-1 Related Classifications

HY-178362 Related Classifications