LY231617
Based on 1 Customer Validation
LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease.
For research use only. We do not sell to patients.
- Purity: 98.13%
- CAS No.: 141545-89-3
- Formula: C17H30ClNO
- Molecular Weight:299.88
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
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Antioxidant Compound Library
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HY-L070
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HY-L178
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Biological Activity
LY231617 (0.25, 1, 5, 10, and 25 μM; overnight) attenuates H2O2 toxicity to hippocampal cultures and shows the best effect at a concertration of 10 μM[1]. LY231617 (5 μM; overnight) attenuates 8-isoprostane production and glutathione depletion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats four-vessel occlusion[2]
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Dosage:50 mg/kg
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Administration:Oral gavage; 50 mg/kg 30 minutes before occlusion
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Result:Significantly protected both the hippocampus and striatum from 30 minutes of four-vessel occlusion.
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Animal Model:Male Wistar rats four-vessel occlusion[2]
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Dosage:20 mg/kg
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Administration:Intravenous injection ; 20 mg/kg 30 minutes after occlusion
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Result:Significantly protected the hippocampus and the striatum when given 30 minutes after the onset of the ischemia at the time of reperfusion.
Chemical Information
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CAS No. 141545-89-3
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Appearance Solid
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Molecular Weight 299.88
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Formula C17H30ClNO
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Color Light yellow to yellow
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SMILES
OC1=C(C(C)(C)C)C=C(CNCC)C=C1C(C)(C)C.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 250 mg/mL (833.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.94 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.94 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Fuson KS, et al. Characterization of LY231617 protection against hydrogen peroxide toxicity. J Neurochem. 1999 Mar;72(3):1154-60. [Content Brief]
[2]. Clemens JA, et al. The antioxidant LY231617 reduces global ischemic neuronal injury in rats. Stroke. 1993 May;24(5):716-22; discussion 722-3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3347 mL | 16.6733 mL | 33.3467 mL | 83.3667 mL |
| 5 mM | 0.6669 mL | 3.3347 mL | 6.6693 mL | 16.6733 mL | |
| 10 mM | 0.3335 mL | 1.6673 mL | 3.3347 mL | 8.3367 mL | |
| 15 mM | 0.2223 mL | 1.1116 mL | 2.2231 mL | 5.5578 mL | |
| 20 mM | 0.1667 mL | 0.8337 mL | 1.6673 mL | 4.1683 mL | |
| 25 mM | 0.1334 mL | 0.6669 mL | 1.3339 mL | 3.3347 mL | |
| 30 mM | 0.1112 mL | 0.5558 mL | 1.1116 mL | 2.7789 mL | |
| 40 mM | 0.0834 mL | 0.4168 mL | 0.8337 mL | 2.0842 mL | |
| 50 mM | 0.0667 mL | 0.3335 mL | 0.6669 mL | 1.6673 mL | |
| 60 mM | 0.0556 mL | 0.2779 mL | 0.5558 mL | 1.3894 mL | |
| 80 mM | 0.0417 mL | 0.2084 mL | 0.4168 mL | 1.0421 mL | |
| 100 mM | 0.0333 mL | 0.1667 mL | 0.3335 mL | 0.8337 mL |
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