BMS-191011 (Synonyms: BMS-A)

Name: BMS-191011
Brand: MedChemExpress
SKU: HY-108593
Rating: 5.0 (3 reviews)

Cat. No.: HY-108593 Purity: 99.56%: Data Sheet
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BMS 191011 (BMS-A) is a potent BK_Ca channel opener (large-conductance Ca²⁺-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke.

For research use only. We do not sell to patients.

CAS No. : 202821-81-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

3 Publications Citing Use of MCE BMS-191011

Cell Proliferation/Viability Assay

: BMS-191011 purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Oct;178(20):4155-4175. [Abstract]; Effect of NaHS on neuronal viability against OGD/R injury in vitro. Cell viability was measured by CCK-8 at 24 h post-reoxygenation. Data: mean ± SD, n=6. #P<0.05 vs Normal; *P<0.05 vs Model (OGD/R); &P<0.05 vs NaHS (1 µM); $P<0.05 vs BMS-191011 (BMS) (10 µM); %P<0.05 vs NaHS+Verapamil (Ver) (100 µM); ※P<0.05 vs Verapamil alone. NNC 55-0396 (NNC): 100 µM.

: BMS-191011 purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Oct;178(20):4155-4175. [Abstract]; Effect of NaHS on neuronal viability against OGD/R injury in vitro. Cell viability was measured by CCK-8 at 24 h post-reoxygenation. Data: mean ± SD, n=6. #P<0.05 vs Normal; *P<0.05 vs Model (OGD/R); &P<0.05 vs NaHS (1 µM); $P<0.05 vs BMS-191011 (BMS) (10 µM); %P<0.05 vs NaHS+Verapamil (Ver) (100 µM); ※P<0.05 vs Verapamil alone. NNC 55-0396 (NNC): 100 µM.

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Description

BMS 191011 (BMS-A) is a potent BK_Ca channel opener (large-conductance Ca²⁺-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke^[1].

In Vitro

BMS-191011 (20 or 40 μM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	IGR39 and Panc-1 cells
Concentration:	20 or 40 µM
Incubation Time:
Result:	Activated BK channels in less than 50% IGR39 cells and led to less than two-fold potentiation in Panc-1 cells. Promoted the activation of a voltage-independent K⁺ conductance at negative voltages.

In Vivo

BMS-191011 (intravenous injection; 10-100 μg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (8- to 10-week-old) treated with Tetrodotoxin (50 µg/kg, intravenously (i.v.)) ^[2]
Dosage:	10-100 µg/kg
Administration:	Intravenous injection; 10-100 µg/kg; once
Result:	Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.

Molecular Weight

370.71

Formula

C₁₆H₁₀ClF₃N₂O₃

CAS No.

202821-81-6

Appearance

Solid

Color

White to off-white

SMILES

O=C1OC(C2=CC=C(C(F)(F)F)C=C2)=NN1CC3=CC(Cl)=CC=C3O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (134.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6975 mL	13.4876 mL	26.9753 mL
5 mM	0.5395 mL	2.6975 mL	5.3951 mL
10 mM	0.2698 mL	1.3488 mL	2.6975 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.56%

Select Batch:

Data Sheet (276 KB) SDS (479 KB)

COA (251 KB) HNMR (197 KB) RP-HPLC (201 KB)

Handling Instructions (2659 KB)

References

[1]. Romine JL, et al. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. J Med Chem. 2007 Feb 8;50(3):528-42. [Content Brief]

[2]. Asami Mori, et al. BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Biol Pharm Bull. 2011;34(1):150-2. [Content Brief]

[3]. Remigante A, et al. NS-11021 Modulates Cancer-Associated Processes Independently of BK Channels in Melanoma and Pancreatic Duct Adenocarcinoma Cell Lines. Cancers (Basel). 2021 Dec 6;13(23):6144. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6975 mL	13.4876 mL	26.9753 mL	67.4382 mL
	5 mM	0.5395 mL	2.6975 mL	5.3951 mL	13.4876 mL
	10 mM	0.2698 mL	1.3488 mL	2.6975 mL	6.7438 mL
	15 mM	0.1798 mL	0.8992 mL	1.7984 mL	4.4959 mL
	20 mM	0.1349 mL	0.6744 mL	1.3488 mL	3.3719 mL
	25 mM	0.1079 mL	0.5395 mL	1.0790 mL	2.6975 mL
	30 mM	0.0899 mL	0.4496 mL	0.8992 mL	2.2479 mL
	40 mM	0.0674 mL	0.3372 mL	0.6744 mL	1.6860 mL
	50 mM	0.0540 mL	0.2698 mL	0.5395 mL	1.3488 mL
	60 mM	0.0450 mL	0.2248 mL	0.4496 mL	1.1240 mL
	80 mM	0.0337 mL	0.1686 mL	0.3372 mL	0.8430 mL
	100 mM	0.0270 mL	0.1349 mL	0.2698 mL	0.6744 mL

BMS-191011 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-191011202821-81-6BMS-ABMS191011BMS 191011Potassium ChannelKcsAneuroprotective activityrodent models of strokeIGR39Panc-1Inhibitorinhibitorinhibit

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BMS-191011 (Synonyms: BMS-A)

Customer Review

BMS-191011 Related Antibodies

3 Publications Citing Use of MCE BMS-191011

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•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

BMS-191011 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

BMS-191011 Related Classifications

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